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dc.contributor.authorLiakatos, Angelaen_US
dc.contributor.authorKiefel, Miltonen_US
dc.contributor.authorFleming, Fionaen_US
dc.contributor.authorCoulson, Barbaraen_US
dc.contributor.authorvon Itzstein, Marken_US
dc.date.accessioned2017-05-03T11:05:43Z
dc.date.available2017-05-03T11:05:43Z
dc.date.issued2006en_US
dc.date.modified2009-10-19T05:23:02Z
dc.identifier.issn09680896en_US
dc.identifier.doi10.1016/j.bmc.2005.08.057en_AU
dc.identifier.urihttp://hdl.handle.net/10072/13716
dc.description.abstractRotaviruses are the most significant cause of gastroenteritis in young children and are responsible for over 600,000 infant deaths annually. The rotaviral haemagglutinin protein (VP8*) of some strains has been implicated in early recognition and binding events of host cell-surface sialoglycoconjugates, and is therefore an attractive target for potential therapeutic intervention. Since N-acetylneuraminic acid a(2,3)-linked to galactose is believed to be the minimum binding epitope of rotavirus to host cells, we report here our development of an efficient and flexible synthetic route to a range of lactose-based sialylmimetics of a(2,3)-linked thiosialosides. These compounds were biologically evaluated as inhibitors of rotaviral infection using an in vitro neutralisation assay. The results suggest that these lactose-based sialylmimetics are not inhibitors of the rhesus rotavirus strain; however, they do exhibit modest inhibition of the human (Wa) strain, presumably through inhibition of the rotaviral adhesion process.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherPergamon Pressen_US
dc.publisher.placeOxford, UKen_US
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/129/description#descriptionen_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom739en_US
dc.relation.ispartofpageto757en_US
dc.relation.ispartofjournalBioorganic & Medicinal Chemistryen_US
dc.relation.ispartofvolume14en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode250301en_US
dc.subject.fieldofresearchcode250302en_US
dc.titleThe synthesis and biological evaluation of lactose-based sialylmimetics as inhibitors of rotaviral infectionen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomicsen_US
gro.date.issued2006
gro.hasfulltextNo Full Text


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