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dc.contributor.authorMann, Marettaen_US
dc.contributor.authorThomson, Robinen_US
dc.contributor.authorDyason, Jeffreyen_US
dc.contributor.authorMcAtamney, Sarahen_US
dc.contributor.authorvon Itzstein, Marken_US
dc.date.accessioned2017-04-24T07:56:29Z
dc.date.available2017-04-24T07:56:29Z
dc.date.issued2006en_US
dc.date.modified2009-10-19T05:24:01Z
dc.identifier.issn09680896en_US
dc.identifier.doi10.1016/j.bmc.2005.10.004en_AU
dc.identifier.urihttp://hdl.handle.net/10072/13717
dc.description.abstractThe development of sialidase inhibitors is an area of continuing interest due to their potential use as therapeutic agents to combat viral and bacterial infections. Herein, we report our studies involving the sialidase from the pathogen Vibrio cholerae, through the modelling, synthesis and biological evaluation of mimetics of 5-acetamido-2,6-anhydro-3,5-dideoxy-d-glycero-d-galacto-non-2-enonic acid (Neu5Ac2en, 1), a naturally occurring sialidase inhibitor. These mimetics are O- and S-glycosides of N-acetyl-d-glucosaminuronic acid in which the aglycone portion effectively replaces the C-6 glycerol side chain of Neu5Ac2en (1). The choice of aglycones was aided by use of the X-ray crystal structure of V. cholerae sialidase complexed with Neu5Ac2en (1). All Neu5Ac2en mimetics tested were found to inhibit V. cholerae sialidase as determined using a standard fluorometric assay.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherPergamonen_US
dc.publisher.placeOxford, UKen_US
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/129/description#descriptionen_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom1518en_US
dc.relation.ispartofpageto1537en_US
dc.relation.ispartofjournalBioorganic & Medicinal Chemistryen_US
dc.relation.ispartofvolume14en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode250301en_US
dc.subject.fieldofresearchcode250302en_US
dc.titleModelling, synthesis and biological evaluation of novel glucoronide-based probes of Vibrio cholerae sialidaseen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2006
gro.hasfulltextNo Full Text


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