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  • Unsaturated N-acetyl-D-glycosaminuronic acid glycosides as inhibitors of influenza virus sialidase

    Author(s)
    Mann, MC
    Islam, T
    Dyason, JC
    Florio, P
    Trower, CJ
    Thomson, RJ
    von Itzstein, M
    Griffith University Author(s)
    von Itzstein, Mark
    Thomson, Robin J.
    Dyason, Jeffrey C.
    Mann, Maretta C.
    Islam, Tasneem
    Year published
    2006
    Metadata
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    Abstract
    The threat of pandemic influenza is a significant concern of governments worldwide. There is a very limited and relatively expensive armament to tackle such a pandemic should it occur. This fact provides much impetus to the scientific community for the discovery of new and less expensive anti-influenza drugs. Our longstanding interest in the inhibition of influenza virus sialidase, coupled with the development of simple carbohydrates that mimic an unsaturated derivative of the enzyme's naturally-occurring ligand, N-acetylneuraminic acid, has led us to investigate the development of influenza virus sialidase inhibitors based ...
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    The threat of pandemic influenza is a significant concern of governments worldwide. There is a very limited and relatively expensive armament to tackle such a pandemic should it occur. This fact provides much impetus to the scientific community for the discovery of new and less expensive anti-influenza drugs. Our longstanding interest in the inhibition of influenza virus sialidase, coupled with the development of simple carbohydrates that mimic an unsaturated derivative of the enzyme's naturally-occurring ligand, N-acetylneuraminic acid, has led us to investigate the development of influenza virus sialidase inhibitors based on these mimetics. We have successfully prepared a range of these compounds, in good yield, from the relatively inexpensive carbohydrate N-acetylglucosamine utilising a short synthetic procedure. We have employed a sialidase inhibition assay for biological evaluation of the target compounds and to our delight these mimetics have displayed significant inhibition of influenza virus sialidase.
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    Journal Title
    Glycoconjugate Journal
    Volume
    23
    DOI
    https://doi.org/10.1007/s10719-006-5445-9
    Subject
    Biochemistry and Cell Biology
    Medical Microbiology
    Neurosciences
    Publication URI
    http://hdl.handle.net/10072/13718
    Collection
    • Journal articles

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