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dc.contributor.authorDyason, Jeffreyen_US
dc.contributor.authorFlorio, Pasen_US
dc.contributor.authorIslam, Tasneemen_US
dc.contributor.authorJ. Trower, Carolynen_US
dc.contributor.authorMann, Marettaen_US
dc.contributor.authorThomson, Robinen_US
dc.contributor.authorvon Itzstein, Marken_US
dc.date.accessioned2017-04-04T14:12:37Z
dc.date.available2017-04-04T14:12:37Z
dc.date.issued2006en_US
dc.date.modified2010-08-26T07:38:28Z
dc.identifier.issn02820080en_US
dc.identifier.doi10.1007/s10719-006-5445-9en_AU
dc.identifier.urihttp://hdl.handle.net/10072/13718
dc.description.abstractThe threat of pandemic influenza is a significant concern of governments worldwide. There is a very limited and relatively expensive armament to tackle such a pandemic should it occur. This fact provides much impetus to the scientific community for the discovery of new and less expensive anti-influenza drugs. Our longstanding interest in the inhibition of influenza virus sialidase, coupled with the development of simple carbohydrates that mimic an unsaturated derivative of the enzyme's naturally-occurring ligand, N-acetylneuraminic acid, has led us to investigate the development of influenza virus sialidase inhibitors based on these mimetics. We have successfully prepared a range of these compounds, in good yield, from the relatively inexpensive carbohydrate N-acetylglucosamine utilising a short synthetic procedure. We have employed a sialidase inhibition assay for biological evaluation of the target compounds and to our delight these mimetics have displayed significant inhibition of influenza virus sialidase.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherSpringeren_US
dc.publisher.placeUSen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom127en_US
dc.relation.ispartofpageto133en_US
dc.relation.ispartofjournalGlycoconjugate Journalen_US
dc.relation.ispartofvolume23en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode250301en_US
dc.subject.fieldofresearchcode250302en_US
dc.titleUnsaturated N-acetyl-D-glycosaminuronic acid glycosides as inhibitors of influenza virus sialidaseen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2006
gro.hasfulltextNo Full Text


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