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dc.contributor.authorHaselhorst, Thomas
dc.contributor.authorStummeyer, Katharina
dc.contributor.authorMuehlenhoff, Martina
dc.contributor.authorSchaper, Wiebke
dc.contributor.authorGerardy-Schahn, Rita
dc.contributor.authorvon Itzstein, Mark
dc.date.accessioned2017-05-03T11:05:46Z
dc.date.available2017-05-03T11:05:46Z
dc.date.issued2006
dc.date.modified2009-10-19T05:23:10Z
dc.identifier.issn1439-4227
dc.identifier.doi10.1002/cbic.200600252
dc.identifier.urihttp://hdl.handle.net/10072/13721
dc.description.abstractPhages infecting the polySia-encapsulated human pathogen E. coli K1 are equipped with capsule-degrading tail spikes known as endosialidases, which are the only identified enzymes that specifically degrade polySia. The X-ray crystallographic structure of endosialidase has been reported but it remains unclear how polySia interacts with the active site. Here we report STD and trNOE NMR experiments that investigate the binding mode of polySia DP5 at a molecular level.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoen_AU
dc.publisherWiley-VCH
dc.publisher.placeGermany
dc.publisher.urihttp://www3.interscience.wiley.com/journal/72510898/home
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1875
dc.relation.ispartofpageto1877
dc.relation.ispartofjournalChemBioChem
dc.relation.ispartofvolume7
dc.rights.retentionY
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchcode0304
dc.subject.fieldofresearchcode0601
dc.titleEndosialidase NF Appears To Bind PolySia DP5 in a Helical Conformation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2006 John Wiley & Sons, Ltd. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please refer to the journal link for access to the definitive, published version or contact the author for more information.
gro.date.issued2006
gro.hasfulltextNo Full Text
gro.griffith.authorvon Itzstein, Mark
gro.griffith.authorHaselhorst, Thomas E.
gro.griffith.authorSchaper, Wiebke


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