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dc.contributor.authorPlebanski, Magdalenaen_US
dc.contributor.authorLopez, Esteren_US
dc.contributor.authorProudfoot, Owenen_US
dc.contributor.authorM. Cook, Brianen_US
dc.contributor.authorvon Itzstein, Marken_US
dc.contributor.authorL. Coppel, Rossen_US
dc.date.accessioned2017-05-03T11:05:46Z
dc.date.available2017-05-03T11:05:46Z
dc.date.issued2006en_US
dc.date.modified2009-10-19T05:25:12Z
dc.identifier.issn10462023en_US
dc.identifier.doi10.1016/j.ymeth.2006.05.021en_AU
dc.identifier.urihttp://hdl.handle.net/10072/13722
dc.description.abstractHerein, we analyze in general the current vaccine market and identify potential factors driving and modulating supply and demand for vaccines. An emphasis is placed on changes in regulation in the last 20 years which have led to increased indirect costs of production, and which can create a barrier against the timely use of technological advances to reduce direct costs. Other defining industry characteristics, such as firm numbers and sizes, cost and pricing strategies, nature extent and impact of Government involvement and international regulation are noted. These considerations, far from being removed from basic vaccine research, influence its ability to achieve aims that can be then progressed into effective vaccine products. We discuss specifically the development of particulate vaccines against malaria, a major lethal disease and health problem prevalent in Africa, including some key economic and methodological challenges and opportunities. We note some practical issues blocking the development of effective particulate vaccines for the Third World, mainly driven by the regulatory spiral noted above.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherAcademic Pressen_US
dc.publisher.placeUnited Statesen_US
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/622914/description#descriptionen_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom77en_US
dc.relation.ispartofpageto85en_US
dc.relation.ispartofjournalMethodsen_US
dc.relation.ispartofvolume40en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode270304en_US
dc.titleEconomic and practical challenges to the formulation of vaccines against endemic infectious diseases such as malariaen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2006
gro.hasfulltextNo Full Text


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