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dc.contributor.authorBurne, Thomasen_US
dc.contributor.authorJohnston, Amyen_US
dc.contributor.authorJ. McGrath, Johnen_US
dc.contributor.authorMackay-Sim, Alanen_US
dc.date.accessioned2017-05-03T11:32:32Z
dc.date.available2017-05-03T11:32:32Z
dc.date.issued2006en_US
dc.date.modified2009-09-22T05:49:03Z
dc.identifier.issn03619230en_US
dc.identifier.doi10.1016/j.brainresbull.2005.10.014en_AU
dc.identifier.urihttp://hdl.handle.net/10072/13864
dc.description.abstractAnimal experiments have shown that Vitamin D plays a role in both brain development and adult brain function. The adult Vitamin D receptor null mutant mouse (VDR -/-) is reported to be less active and more anxious than wild-type litter mate controls and to have poor swimming ability. However, an "anxious" behavioural phenotype is inferred from differences in locomotor behaviour. This is a general problem in behavioural phenotyping where a neurological phenotype is inferred from changes in locomotion which will be affected by non-neurological factors, such as muscle fatigue. In this study of VDR -/-, we conducted a detailed examination of one form of motor behaviour, swimming, compared to wildtype littermate controls. Swimming was assessed using a forced swim test, a laneway swimming test and a watermaze test using a visible platform. Post-swimming activity was assessed by comparing grooming and rearing behaviour before, and 5min after, the forced swimming test. We replicated previous findings in which VDR -/- mice demonstrate more sinking episodes than wildtype controls in the forced swim test but they were similar to controls in the time taken to swim a 1m laneway, and in the time taken to reach a visible platform in the watermaze. Thus, the VDR -/- mice were able to swim but were not able to float. Grooming and rearing behaviour of the VDR -/- mice was similar to wildtype controls before the forced swim but the VDR -/- were much less active after the swim compared with wildtype mice which displayed high levels of grooming and rearing. We conclude that VDR -/- mice have muscular and motor impairments that do not affect their ability to swim but significantly alters the ability to float as well as their post-swimming activity. Differences in muscle strength may confound tests of activity that are used to infer an "anxious" phenotype.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevieren_US
dc.publisher.placeLondonen_US
dc.publisher.urihttp://www.sciencedirect.com/science/journal/03619230en_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom74en_US
dc.relation.ispartofpageto78en_US
dc.relation.ispartofjournalBrain Research Bulletinen_US
dc.relation.ispartofvolume69en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode320702en_US
dc.titleSwimming behaviour and post-swimming activity in Vitamin D receptor knockout miceen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2006
gro.hasfulltextNo Full Text


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