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dc.contributor.authorSvingen, T
dc.contributor.authorTonissen, KF
dc.contributor.editorProfessor Richard A Nichols
dc.date.accessioned2017-05-03T13:22:25Z
dc.date.available2017-05-03T13:22:25Z
dc.date.issued2006
dc.date.modified2007-08-07T04:33:26Z
dc.identifier.issn0018-067X
dc.identifier.urihttp://hdl.handle.net/10072/13868
dc.description.abstractThe Hox family of homeodomain transcription factors regulate numerous pathways during developmental and normal cellular processes. All Hox proteins recognise similar sequences in vitro yet display functional diversity in an in vivo environment. This review focuses on the transcriptional and functional specificity elicited by Hox proteins, giving an overview of homeodomain-DNA interactions and the gain of binding specificity through cooperative binding with cofactors. Furthermore, currently identified mammalian Hox target genes are presented, of which the most striking feature is that very few direct Hox targets have been identified. The direct targets participate in an array of cellular functions including organogenesis and cellular differentiation, cell adhesion and migration and cell cycle and apoptotic pathways. A further assessment of identified mammalian promoter targets and the contribution of bases outside the canonical recognition motif is given, highlighting roles they may play in either trans-activation or repression by Hox proteins.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.publisher.placeUnited Kingdom
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom88
dc.relation.ispartofpageto96
dc.relation.ispartofjournalHeredity
dc.relation.ispartofvolume97
dc.rights.retentionY
dc.subject.fieldofresearchEvolutionary biology
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchcode3104
dc.subject.fieldofresearchcode3105
dc.titleHox transcription factors and their elusive mammalian gene targets
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2006
gro.hasfulltextNo Full Text
gro.griffith.authorTonissen, Kathryn F.
gro.griffith.authorSvingen, Terje


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