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dc.contributor.authorMcArdle, BM
dc.contributor.authorCampitelli, MR
dc.contributor.authorQuinn, RJ
dc.date.accessioned2017-05-03T14:07:12Z
dc.date.available2017-05-03T14:07:12Z
dc.date.issued2006
dc.date.modified2008-11-21T03:21:21Z
dc.identifier.issn0163-3864
dc.identifier.doi10.1021/np050229y
dc.identifier.urihttp://hdl.handle.net/10072/13869
dc.description.abstractThe relationship between a natural product's biosynthetic enzyme and its therapeutic target is unknown. The concept of protein fold topologies, as a determining factor in recognition, has been developed through molecular modeling techniques. We have shown that biosynthetic enzymes and the therapeutic targets of three classes of natural products that inhibit protein kinases share a common protein fold topology (PFT) and cavity recognition points despite having different fold type classifications. The clinical agent flavopiridol would have been identified by this new approach.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.publisher.placeU.S.
dc.publisher.urihttp://pubs.acs.org/journal/jnprdf
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrom14
dc.relation.ispartofpageto17
dc.relation.ispartofissue1
dc.relation.ispartofjournalJournal of Natural Products
dc.relation.ispartofvolume69
dc.rights.retentionY
dc.subject.fieldofresearchChemical Sciences
dc.subject.fieldofresearchBiological Sciences
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode03
dc.subject.fieldofresearchcode06
dc.subject.fieldofresearchcode11
dc.titleA Common Protein Fold Topology Shared by Flavonoid Biosynthetic Enzymes and Therapeutic Targets.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this publisher. The contents of this journal can be freely accessed online via the ACS web page after publication. Use hypertext link above to access the ACS website.
gro.date.issued2006
gro.hasfulltextNo Full Text
gro.griffith.authorQuinn, Ronald J.
gro.griffith.authorMcArdle, Bernadette M.
gro.griffith.authorCampitelli, Marc R.


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