dc.contributor.author | McArdle, BM | |
dc.contributor.author | Campitelli, MR | |
dc.contributor.author | Quinn, RJ | |
dc.date.accessioned | 2017-05-03T14:07:12Z | |
dc.date.available | 2017-05-03T14:07:12Z | |
dc.date.issued | 2006 | |
dc.date.modified | 2008-11-21T03:21:21Z | |
dc.identifier.issn | 0163-3864 | |
dc.identifier.doi | 10.1021/np050229y | |
dc.identifier.uri | http://hdl.handle.net/10072/13869 | |
dc.description.abstract | The relationship between a natural product's biosynthetic enzyme and its therapeutic target is unknown. The concept of protein fold topologies, as a determining factor in recognition, has been developed through molecular modeling techniques. We have shown that biosynthetic enzymes and the therapeutic targets of three classes of natural products that inhibit protein kinases share a common protein fold topology (PFT) and cavity recognition points despite having different fold type classifications. The clinical agent flavopiridol would have been identified by this new approach. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | American Chemical Society | |
dc.publisher.place | U.S. | |
dc.publisher.uri | http://pubs.acs.org/journal/jnprdf | |
dc.relation.ispartofstudentpublication | Y | |
dc.relation.ispartofpagefrom | 14 | |
dc.relation.ispartofpageto | 17 | |
dc.relation.ispartofissue | 1 | |
dc.relation.ispartofjournal | Journal of Natural Products | |
dc.relation.ispartofvolume | 69 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Chemical sciences | |
dc.subject.fieldofresearch | Biological sciences | |
dc.subject.fieldofresearch | Biomedical and clinical sciences | |
dc.subject.fieldofresearchcode | 34 | |
dc.subject.fieldofresearchcode | 31 | |
dc.subject.fieldofresearchcode | 32 | |
dc.title | A Common Protein Fold Topology Shared by Flavonoid Biosynthetic Enzymes and Therapeutic Targets. | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.rights.copyright | Self-archiving of the author-manuscript version is not yet supported by this publisher. The contents of this journal can be freely accessed online via the ACS web page after publication. Use hypertext link above to access the ACS website. | |
gro.date.issued | 2006 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Quinn, Ronald J. | |