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dc.contributor.authorCurtain, Rob
dc.contributor.authorSmith, Robert
dc.contributor.authorOvcaric, Micky
dc.contributor.authorGriffiths, Lyn
dc.date.accessioned2017-05-03T12:16:04Z
dc.date.available2017-05-03T12:16:04Z
dc.date.issued2006
dc.date.modified2009-01-27T06:13:39Z
dc.identifier.issn0887-8994
dc.identifier.doi10.1016/j.pediatrneurol.2005.08.033
dc.identifier.urihttp://hdl.handle.net/10072/14068
dc.description.abstractFamilial hemiplegic migraine is a severe, rare subtype of migraine. Gene mutations on chromosome 19 have been identified in the calcium channel, voltage-dependent, P/Q type, alpha-1A subunit gene (chromosome 19p13) for familial hemiplegic migraine. Recently a gene mutation (Serine-218-Leucine) for a dramatic syndrome associated with familial hemiplegic migraine, commonly named "migraine coma", has implicated exon 5 of this gene. The occurrence of trivial head trauma, in such familial hemiplegic migraine patients, may also be complicated by severe, sometimes even fatal, cerebral edema and coma occurring after a lucid interval. Sporadic hemiplegic migraine shares a similar spectrum of clinical presentation and genetic heterogeneity. The case report presented in this article implicates the involvement of the Serine-218-Leucine mutation in the extremely rare disorder of minor head trauma-induced migraine coma. We conclude that the Serine-218-Leucine mutation in the calcium channel, voltage-dependent, P/Q type, alpha-1A subunit gene is involved in sporadic hemiplegic migraine, delayed cerebral edema and coma after minor head trauma.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited States
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/524904/description#description
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrom329
dc.relation.ispartofpageto332
dc.relation.ispartofjournalPediatric Neurology
dc.relation.ispartofvolume34
dc.rights.retentionY
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchcode3209
dc.titleMinor Head Trauma Induced Sporadic Hemiplegic Migraine (SHM) Coma
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.date.issued2006
gro.hasfulltextNo Full Text
gro.griffith.authorGriffiths, Lyn
gro.griffith.authorCurtain, Rob
gro.griffith.authorSmith, Robert A.
gro.griffith.authorOvcaric, Micky


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    Contains articles published by Griffith authors in scholarly journals.

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