dc.contributor.author | Curtain, Rob | |
dc.contributor.author | Smith, Robert | |
dc.contributor.author | Ovcaric, Micky | |
dc.contributor.author | Griffiths, Lyn | |
dc.date.accessioned | 2017-05-03T12:16:04Z | |
dc.date.available | 2017-05-03T12:16:04Z | |
dc.date.issued | 2006 | |
dc.date.modified | 2009-01-27T06:13:39Z | |
dc.identifier.issn | 0887-8994 | |
dc.identifier.doi | 10.1016/j.pediatrneurol.2005.08.033 | |
dc.identifier.uri | http://hdl.handle.net/10072/14068 | |
dc.description.abstract | Familial hemiplegic migraine is a severe, rare subtype of migraine. Gene mutations on chromosome 19 have been identified in the calcium channel, voltage-dependent, P/Q type, alpha-1A subunit gene (chromosome 19p13) for familial hemiplegic migraine. Recently a gene mutation (Serine-218-Leucine) for a dramatic syndrome associated with familial hemiplegic migraine, commonly named "migraine coma", has implicated exon 5 of this gene. The occurrence of trivial head trauma, in such familial hemiplegic migraine patients, may also be complicated by severe, sometimes even fatal, cerebral edema and coma occurring after a lucid interval. Sporadic hemiplegic migraine shares a similar spectrum of clinical presentation and genetic heterogeneity. The case report presented in this article implicates the involvement of the Serine-218-Leucine mutation in the extremely rare disorder of minor head trauma-induced migraine coma. We conclude that the Serine-218-Leucine mutation in the calcium channel, voltage-dependent, P/Q type, alpha-1A subunit gene is involved in sporadic hemiplegic migraine, delayed cerebral edema and coma after minor head trauma. | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.publisher.place | United States | |
dc.publisher.uri | http://www.elsevier.com/wps/find/journaldescription.cws_home/524904/description#description | |
dc.relation.ispartofstudentpublication | Y | |
dc.relation.ispartofpagefrom | 329 | |
dc.relation.ispartofpageto | 332 | |
dc.relation.ispartofjournal | Pediatric Neurology | |
dc.relation.ispartofvolume | 34 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Neurosciences | |
dc.subject.fieldofresearchcode | 3209 | |
dc.title | Minor Head Trauma Induced Sporadic Hemiplegic Migraine (SHM) Coma | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.faculty | Griffith Health, School of Medical Science | |
gro.date.issued | 2006 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Griffiths, Lyn | |
gro.griffith.author | Curtain, Rob | |
gro.griffith.author | Smith, Robert A. | |
gro.griffith.author | Ovcaric, Micky | |