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  • Dendritic cell immunotherapy for breast cancer

    Author(s)
    Pinzon-Charry, Alberto
    Schmidt, Chris
    Lopez, Jose Alejandro
    Griffith University Author(s)
    Lopez Ramirez, Alejandro
    Pinzon-Charry, Alberto
    Year published
    2006
    Metadata
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    Abstract
    Novel adjuvant therapies are urgently needed to complement the existing treatment options for breast cancer. The advent of the use of dendritic cells (DCs) for cancer immunotherapy provides a unique opportunity to overcome the relative non-immunogenic property of breast tumours and address the underlying immunodeficiency. To date, the success of this approach has been limited, possibly due to the targeting of specific tumour antigens that rapidly mutate and, thus, become undetectable to the immune system. A more efficient approach would include preparations encompassing multiple antigens, such as those provided by loading ...
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    Novel adjuvant therapies are urgently needed to complement the existing treatment options for breast cancer. The advent of the use of dendritic cells (DCs) for cancer immunotherapy provides a unique opportunity to overcome the relative non-immunogenic property of breast tumours and address the underlying immunodeficiency. To date, the success of this approach has been limited, possibly due to the targeting of specific tumour antigens that rapidly mutate and, thus, become undetectable to the immune system. A more efficient approach would include preparations encompassing multiple antigens, such as those provided by loading of whole tumour cells or tumour RNA. It is proposed that targeting mammary stem cells responsible for resistance to chemo/immunotherapy, through the expression of a broad array of wild-type and mutated tumour antigens in the context of DCs, will become a mainstay for immunotherapy of breast cancer.
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    Journal Title
    Expert Opinion on Biological Therapy
    Volume
    6
    Issue
    6
    Publisher URI
    http://informahealthcare.com/loi/ebt
    DOI
    https://doi.org/10.1517/14712598.6.6.591
    Subject
    Biomedical and clinical sciences
    Publication URI
    http://hdl.handle.net/10072/14087
    Collection
    • Journal articles

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