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dc.contributor.authorPerchyonok, V Tamara
dc.contributor.authorReher, Vanessa
dc.contributor.authorZhang, Shengmiao
dc.contributor.authorBasson, Nicki
dc.contributor.authorGrobler, Sias
dc.date.accessioned2017-09-17T22:56:28Z
dc.date.available2017-09-17T22:56:28Z
dc.date.issued2014
dc.identifier.issn2079-4983
dc.identifier.doi10.3390/jfb5040259
dc.identifier.urihttp://hdl.handle.net/10072/141048
dc.description.abstractHealing is a specific biological process related to the general phenomenon of growth and tissue regeneration and is a process generally affected by several systemic conditions or as detrimental side-effects of chemotherapy- and radiotherapy-induced inflammation of the oral mucosa. The objectives of this study is to evaluate the novel chitosan based functional drug delivery systems, which can be successfully incorporated into “dual action bioactive restorative materials”, capable of inducing in vitro improved wound healing prototype and containing an antibiotic, such as nystatin, krill oil as an antioxidant and hydroxyapatite as a molecular bone scaffold, which is naturally present in bone and is reported to be successfully used in promoting bone integration when implanted as well as promoting healing. The hydrogels were prepared using a protocol as previously reported by us. The physico-chemical features, including surface morphology (SEM), release behaviors, stability of the therapeutic agent-antioxidant-chitosan, were measured and compared to the earlier reported chitosan-antioxidant containing hydrogels. Structural investigations of the reactive surface of the hydrogel are reported. Release of nystatin was investigated for all newly prepared hydrogels. Bio-adhesive studies were performed in order to assess the suitability of these designer materials. Free radical defense capacity of the biomaterials was evaluated using established in vitro model. The bio-adhesive capacity of the materials in the in vitro system was tested and quantified. It was found that the favorable synergistic effect of free radical built-in defense mechanism of the new functional materials increased sustainable bio-adhesion and therefore acted as a functional multi-dimensional restorative material with potential application in wound healing in vitro.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherM D P I AG
dc.publisher.placeSwitzerland
dc.relation.ispartofpagefrom259
dc.relation.ispartofpageto272
dc.relation.ispartofissue4
dc.relation.ispartofjournalJournal of Functional Biomaterials
dc.relation.ispartofvolume5
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchBiomedical Engineering
dc.subject.fieldofresearchMedical Biotechnology
dc.subject.fieldofresearchcode119999
dc.subject.fieldofresearchcode0903
dc.subject.fieldofresearchcode1004
dc.titleEvaluation of Nystatin Containing Chitosan Hydrogels as Potential Dual Action Bio-Active Restorative Materials: in Vitro Approach
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionPublished
gro.rights.copyright© 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorReher, Vanessa G.


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