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dc.contributor.authorLui, Simon SY
dc.contributor.authorWang, Ya
dc.contributor.authorYang, Tian-xiao
dc.contributor.authorLiu, Amy CY
dc.contributor.authorChui, William WH
dc.contributor.authorYeung, Hera KH
dc.contributor.authorLi, Zhi
dc.contributor.authorNeumann, David L
dc.contributor.authorShum, David HK
dc.contributor.authorCheung, Eric FC
dc.contributor.authorChan, Raymond CK
dc.date.accessioned2017-11-29T12:00:58Z
dc.date.available2017-11-29T12:00:58Z
dc.date.issued2015
dc.identifier.issn0022-3956
dc.identifier.doi10.1016/j.jpsychires.2014.11.007
dc.identifier.urihttp://hdl.handle.net/10072/141066
dc.description.abstractProspective memory (PM) is the ability to remember to carry out intended actions in the future. Empirical evidence suggests that PM deficits exist in individuals with chronic schizophrenia. However, it is unclear whether PM deficits in first-episode schizophrenia exist independently from other neuropsychological deficits. Moreover, prior research using patients with first-episode has been limited to small inpatient samples. We aimed to clarify the nature and extent of PM deficits in individuals with first-episode schizophrenia, using a large outpatient sample. Participants were 91 clinically stable outpatients with first-episode schizophrenia and 83 healthy controls. PM was assessed using both a subjective self-reported checklist and a laboratory-based task capturing time- and event-based PM. A battery assessing verbal and visuo-spatial working memory, as well as executive functions was also administered. ANOVA analyses showed that patients with first-episode schizophrenia performed significantly poorer than healthy controls in time- and event-based PM. Stepwise linear regression analyses suggested that cognitive flexibility predicted time- and event-based PM; and working memory predicted event-based PM. Subgroup analyses showed that “cognitive-preserved” patients with first-episode schizophrenia tended to perform poorer in time-based PM deficit than healthy controls who were matched in IQ and other neuropsychological functions. Overall, our results provide substantial evidence to support that time-based PM deficits in first-episode schizophrenia are apparent and not entirely attributable to other neuropsychological deficits. PM may constitute a neuropsychological marker for schizophrenia.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherPergamon
dc.relation.ispartofpagefrom141
dc.relation.ispartofpageto149
dc.relation.ispartofjournalJournal of Psychiatric Research
dc.relation.ispartofvolume61
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode52
dc.titleProblems in remembering to carry out future actions in first-episode schizophrenia: Primary or secondary impairment?
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorNeumann, David L.


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