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dc.contributor.authorHsu, Fang-Chi
dc.contributor.authorRaffield, Laura M
dc.contributor.authorHugenschmidt, Christina E
dc.contributor.authorCox, Amanda
dc.contributor.authorXu, Jianzhao
dc.contributor.authorCarr, J Jeffery
dc.contributor.authorFreedman, Barry I
dc.contributor.authorMaldjian, Joseph A
dc.contributor.authorWilliamson, Jeff D
dc.contributor.authorBowden, Donald W
dc.date.accessioned2018-10-03T02:45:05Z
dc.date.available2018-10-03T02:45:05Z
dc.date.issued2015
dc.identifier.issn0251-5350
dc.identifier.doi10.1159/000435775
dc.identifier.urihttp://hdl.handle.net/10072/141102
dc.description.abstractBackground: Type 2 diabetes mellitus increases the risk of cognitive decline and dementia, and elevated burdens of vascular disease are hypothesized to contribute to this risk. These relationships were examined in the Diabetes Heart Study-MIND using a battery of cognitive tests, neuroimaging measures and subclinical cardiovascular disease (CVD) burden assessed by coronary artery calcified (CAC) plaque. We hypothesized that CAC would attenuate the association between neuroimaging measures and cognition performance. Methods: Associations were examined using marginal models in this family-based cohort of 572 European Americans from 263 families. All models were adjusted for age, gender, education, type 2 diabetes and hypertension, with some neuroimaging measures additionally adjusted for intracranial volume. Results: Higher total brain volume was associated with better performance on the Digit Symbol Substitution Task and Semantic Fluency (both p ≤ 7.0 í 10-4). Higher gray matter volume was associated with better performance on the Modified Mini-Mental State Examination and Semantic Fluency (both p ≤ 9.0 í 10-4). Adjusting for CAC caused minimal changes to the results. Conclusions: Relationships exist between neuroimaging measures and cognitive performance in a type 2 diabetes-enriched European American cohort. Associations were minimally attenuated after adjusting for subclinical CVD. Additional work is needed to understand how subclinical CVD burden interacts with other factors and impacts relationships between neuroimaging and cognitive testing measures.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherS. Karger AG
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto11
dc.relation.ispartofissue1
dc.relation.ispartofjournalNeuroepidemiology
dc.relation.ispartofvolume45
dc.subject.fieldofresearchNeurosciences not elsewhere classified
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode110999
dc.subject.fieldofresearchcode1109
dc.subject.fieldofresearchcode1117
dc.titleRelationships between Cognitive Performance, Neuroimaging and Vascular Disease: The DHS-MIND Study
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2015 S. Karger AG, Basel. This is the peer-reviewed but unedited manuscript version of the following article: Relationships between Cognitive Performance, Neuroimaging and Vascular Disease: The DHS-MIND Study, 2015, Vol.45, No. 1, Page 1-11. The final, published version is available at https://doi.org/10.1159/000435775
gro.hasfulltextFull Text
gro.griffith.authorCox, Amanda J.


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