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  • A convenient preparation of diversely substituted fused 2-amino- and 2-alkylthionicotinonitriles under microwave irradiation

    Author(s)
    Krasavin, Mikhail
    V. Sapegin, Alexander
    V. Dorogov, Mikhail
    Griffith University Author(s)
    Krasavin, Mikhail
    Year published
    2015
    Metadata
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    Abstract
    We describe a convenient and operationally simple protocol to prepare nicotinonitriles fused to either a cycloalkane or a saturated heterocycle, containing diverse substituents at position 2 of the nicotinonitrile core, under microwave irradiation. The protocol is useful for rapid and automated synthesis of the target compounds. An unusual case of the loss of a tert-butyl group is observed when tert-butylamine was used to bring about the pyridine ring formation.We describe a convenient and operationally simple protocol to prepare nicotinonitriles fused to either a cycloalkane or a saturated heterocycle, containing diverse substituents at position 2 of the nicotinonitrile core, under microwave irradiation. The protocol is useful for rapid and automated synthesis of the target compounds. An unusual case of the loss of a tert-butyl group is observed when tert-butylamine was used to bring about the pyridine ring formation.
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    Journal Title
    Tetrahedron Letters
    Volume
    56
    Issue
    1
    DOI
    https://doi.org/10.1016/j.tetlet.2014.09.067
    Subject
    Chemical Sciences not elsewhere classified
    Medicinal and Biomolecular Chemistry
    Organic Chemistry
    Publication URI
    http://hdl.handle.net/10072/141148
    Collection
    • Journal articles

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