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dc.contributor.authorAlayan, Jamil
dc.contributor.authorVaquette, Cedryck
dc.contributor.authorSaifzadeh, Siamak
dc.contributor.authorHutmacher, Dietmar
dc.contributor.authorIvanovski, Saso
dc.date.accessioned2018-07-18T03:11:07Z
dc.date.available2018-07-18T03:11:07Z
dc.date.issued2016
dc.identifier.issn0905-7161
dc.identifier.doi10.1111/clr.12652
dc.identifier.urihttp://hdl.handle.net/10072/141216
dc.description.abstractObjective: To histomorphometrically compare the use of collagen-stabilized anorganic bovine bone (ABBM-C) (test) to anorganic bovine bone + autogenous bone (ABBM + AB) (control) in maxillary sinus augmentation. Materials and methods: Nine sheep underwent bilateral sinus augmentation. Each sinus was randomized to receive either control or test bone graft. Three animals were sacrificed at 8 weeks, and six animals were sacrificed at 16 weeks post-grafting. The 18 sinuses were processed for histomorphometry, which assessed the area fraction of new bone (%NB), residual graft (%RG) and soft tissue components (% STM), as well as graft particle osseointegration (% OI), within three zones equally distributed from the augmented sinus floor. Results: At week 16, a significant increase in %NB was evident across all three zones in the control group when compared to week 8. A significantly greater %NB was evident in the control group when compared to the test group in zones 2 (P < 0.001) and 3 (P < 0.001). There was a significant increase in %OI in week 16 when compared to week 8 across all three zones in the control group (P < 0.001). %OI in the control group was significantly greater across all three zones when compared to the test group at week 16 (P < 0.001). Zone was found to be a significant main effect (P < 0.001) that was independent of time and treatment with decreasing %OI in distant zones. % RG did not significantly change with time for both groups. There was a significant reduction in % ST in week 16 when compared to week 8 across all three zones in the control group (P < 0.001). % ST in the test group was significantly greater across all zones when compared to the control group at week 16 (P < 0.001). Conclusion: Both groups exhibited very similar histomorphometric measurements in the zones proximal to the resident sinus wall. The % NB and % OI were greatest in the zones proximal to resident bony walls and gradually decreased as the distance from the proximal walls increased. There was greater % NB and % OI in the control group when compared to the test group in the distant zone.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing
dc.relation.ispartofpagefrom734
dc.relation.ispartofpageto743
dc.relation.ispartofissue6
dc.relation.ispartofjournalClinical Oral Implants Research
dc.relation.ispartofvolume27
dc.subject.fieldofresearchDentistry not elsewhere classified
dc.subject.fieldofresearchBiomedical Engineering
dc.subject.fieldofresearchDentistry
dc.subject.fieldofresearchcode110599
dc.subject.fieldofresearchcode0903
dc.subject.fieldofresearchcode1105
dc.titleA histomorphometric assessment of collagen-stabilized anorganic bovine bone mineral in maxillary sinus augmentation - a randomized controlled trial in sheep
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Dentistry and Oral Health
gro.hasfulltextNo Full Text
gro.griffith.authorIvanovski, Saso
gro.griffith.authorAlayan, Jamil
gro.griffith.authorVaquette, Cedryck
gro.griffith.authorHutmacher, Dietmar W.


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