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dc.contributor.authorPeel, Margaret M
dc.contributor.authorCooke, Marie
dc.contributor.authorLewis-Peel, Helen J
dc.contributor.authorLea, Rodney A
dc.contributor.authorMoyle, Wendy
dc.date.accessioned2018-07-30T01:30:33Z
dc.date.available2018-07-30T01:30:33Z
dc.date.issued2015
dc.identifier.issn0965-2299
dc.identifier.doi10.1016/j.ctim.2015.09.002
dc.identifier.urihttp://hdl.handle.net/10072/141535
dc.description.abstractObjective: To determine if coenzyme Q10 alleviates fatigue in the late-onset sequelae of poliomyelitis. Design: Parallel-group, randomized, placebo-controlled trial. Background setting: Coenzyme Q10 has been shown to boost muscle energy metabolism in post-polio subjects but it does not promote muscle strength, endurance or function in polio survivors with postpoliomyelitis syndrome. However, the collective increased energy metabolism might contribute to a reduction in post-polio fatigue. Participants: Polio survivors from theAustralian post-polio networks in Queensland and New SouthWales who attribute a moderate to high level of fatigue to their diagnosed late-onset sequelae of poliomyelitis. Those withfatigue-associated comorbidities of diabetes, anaemia,hypothyroidismandfibromyalgia were excluded. Method: Participants were assigned (1:1), with stratification ofthose who use energy-savingmobility aids, to receive 100 mg coenzyme Q10 or matching placebo daily for 60 days. Participants and investigators were blinded to group allocation. Fatigue was assessed by the Multidimensional Assessment of Fatigue as the primary outcome and the Fatigue Severity Scale as secondary outcome. Results: Of 103 participants, 54 were assigned to receive coenzyme Q10 and 49 to receive the placebo. The difference in the mean score reductions between the two groups was not statistically significant for either fatigue measure. Oral supplementation with coenzyme Q10 was safe and well-tolerated. Conclusion:Adaily dose of 100 mg coenzyme Q10 for 60 days does not alleviate the fatigue ofthe late-onset sequelae of poliomyelitis.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom789
dc.relation.ispartofpageto793
dc.relation.ispartofissue6
dc.relation.ispartofjournalComplementary Therapies in Medicine
dc.relation.ispartofvolume23
dc.subject.fieldofresearchComplementary and Alternative Medicine not elsewhere classified
dc.subject.fieldofresearchComplementary and Alternative Medicine
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode110499
dc.subject.fieldofresearchcode1104
dc.subject.fieldofresearchcode1701
dc.titleA randomized controlled trial of coenzyme Q10 for fatigue in the late-onset sequelae of poliomyelitis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorCooke, Marie L.
gro.griffith.authorMoyle, Wendy


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