Show simple item record

dc.contributor.authorDahiya, Rachana
dc.contributor.authorShultz, Sarah P
dc.contributor.authorDahiya, Arun
dc.contributor.authorFu, Jinlin
dc.contributor.authorFlatley, Christopher
dc.contributor.authorDuncan, Danusia
dc.contributor.authorCardinal, John
dc.contributor.authorKostner, Karam M
dc.contributor.authorByrne, Nuala M
dc.contributor.authorHills, Andrew P
dc.contributor.authorHarris, Mark
dc.contributor.authorConwell, Louise S
dc.contributor.authorLeong, Gary M
dc.date.accessioned2018-12-07T02:24:28Z
dc.date.available2018-12-07T02:24:28Z
dc.date.issued2015
dc.identifier.issn0002-9149
dc.identifier.doi10.1016/j.amjcard.2015.02.005
dc.identifier.urihttp://hdl.handle.net/10072/141639
dc.description.abstractInsulin resistance (IR) and inflammation are associated with an increased risk of cardiovascular disease and may contribute to obesity cardiomyopathy. The earliest sign of obesity cardiomyopathy is impaired left ventricular (LV) diastolic function, which may be evident in obese children and adolescents. However, the precise metabolic basis of the impaired LV diastolic function remains unknown. The aims of this study were to evaluate cardiac structure and LV diastolic function by tissue Doppler imaging in overweight and obese (OW) youth and to assess the relative individual contributions of adiposity, IR, and inflammation to alterations in cardiac structure and function. We studied 35 OW (body mass index standard deviation score 2.0 ± 0.8; non-IR n = 19, IR n = 16) and 34 non-OW youth (body mass index standard deviation score 0.1 ± 0.7). LV diastolic function was reduced in OW youth compared with non-OW controls, as indicated by lower peak myocardial relaxation velocities (p <0.001) and greater filling pressures (p <0.001). OW youth also had greater LV mass index (p <0.001), left atrial volume index, and LV interventricular septal thickness (LV-IVS; both p = 0.02). IR-OW youth had the highest LV filling pressures, LV-IVS, and relative wall thickness (all p <0.05). Homeostasis model of assessment–insulin resistance and C-reactive protein were negative determinants of peak myocardial relaxation velocity and positive predictors of filling pressure. Adiponectin was a negative determinant of LV-IVS, independent of obesity. In conclusion, OW youth with IR and inflammation are more likely to have adverse changes to cardiovascular structure and function which may predispose to premature cardiovascular disease in adulthood.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom1222
dc.relation.ispartofpageto1228
dc.relation.ispartofissue9
dc.relation.ispartofjournalAmerican Journal of Cardiology
dc.relation.ispartofvolume115
dc.subject.fieldofresearchCardiovascular medicine and haematology
dc.subject.fieldofresearchcode3201
dc.titleRelation of Reduced Preclinical Left Ventricular Diastolic Function and Cardiac Remodeling in Overweight Youth to Insulin Resistance and Inflammation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorHills, Andrew
gro.griffith.authorDahiya, Arun


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record