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  • Evaluation of Respiration of Mitochondria in Cancer Cells Exposed to Mitochondria-Targeted Agents

    Author(s)
    Kluckova, K
    Dong, LF
    Bajzikova, M
    Rohlena, J
    Neuzil, J
    Griffith University Author(s)
    Neuzil, Jiri
    Year published
    2015
    Metadata
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    Abstract
    Respiration is one of the major functions of mitochondria, whereby these vital organelles use oxygen to produce energy. Many agents that may be of potential clinical relevance act by targeting mitochondria, where they may suppress mitochondrial respiration. It is therefore important to evaluate this process and understand how this is modulated by small molecules. Here, we describe the general methodology to assess respiration in cultured cells, followed by the evaluation of the effect of one anticancer agent targeted to mitochondria on this process, and also how to assess this in tumor tissue.Respiration is one of the major functions of mitochondria, whereby these vital organelles use oxygen to produce energy. Many agents that may be of potential clinical relevance act by targeting mitochondria, where they may suppress mitochondrial respiration. It is therefore important to evaluate this process and understand how this is modulated by small molecules. Here, we describe the general methodology to assess respiration in cultured cells, followed by the evaluation of the effect of one anticancer agent targeted to mitochondria on this process, and also how to assess this in tumor tissue.
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    Book Title
    Mitochondrial Medicine
    Volume
    2
    DOI
    https://doi.org/10.1007/978-1-4939-2288-8_14
    Subject
    Other chemical sciences
    Biochemistry and cell biology
    Biochemistry and cell biology not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/141648
    Collection
    • Book chapters

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