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dc.contributor.authorPhad, Neelkanth
dc.contributor.authorDahlstrom, Jane E
dc.contributor.authorEllwood, David
dc.contributor.authorKent, Alison L
dc.date.accessioned2018-09-21T01:00:37Z
dc.date.available2018-09-21T01:00:37Z
dc.date.issued2015
dc.identifier.issn0004-8666
dc.identifier.doi10.1111/ajo.12308
dc.identifier.urihttp://hdl.handle.net/10072/141793
dc.description.abstractAim: To assess the effect of pregnancy-induced hypertensive disorders on the growth of the placenta on the short and long axes and neonatal outcomes. Materials and Methods: A retrospective cohort study of gross and histological characteristics of placentas and the fetal outcomes of normotensive and hypertensive pregnancies over a three-year period from January 2009 to December 2011 at a tertiary teaching hospital in ACT, Australia. Results: Placentas and neonatal outcomes from 100 pregnancies complicated with pregnancy-induced hypertension/preeclampsia were studied and compared with 51 gestational age-matched placentas and neonatal outcomes from normotensive pregnancies. The median maternal age and smoking history were similar in the two groups (P = 0.894; P = 1.00, respectively). The median pre-pregnancy weight was significantly higher (P < 0.001) and primiparity more common (P = 0.001) in the study group. The median weight of the placenta was significantly lower (P < 0.001) and below the 10th centile (P < 0.001) in the study group. Both the long and short axes of the placental disc were significantly smaller in the study group (P = 0.002; P ≤ 0.001 respectively). Accelerated villous maturation, placental infarcts and decidual vessel vasculopathy were more common in the study group (P < 0.001). The median birthweight and the number of infants with birthweight and length below the 10th centile were significantly higher in the study group (P = 0.008; P < 0.001; P = 0.004, respectively). Conclusion: This study demonstrates that pregnancy-induced hypertension significantly influences the growth and development of both the placenta and fetus
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing Asia
dc.publisher.placeAustralia
dc.relation.ispartofpagefrom239
dc.relation.ispartofpageto244
dc.relation.ispartofissue3
dc.relation.ispartofjournalAustralian and New Zealand Journal of Obstetrics and Gynaecology
dc.relation.ispartofvolume55
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchPaediatrics and Reproductive Medicine
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode119999
dc.subject.fieldofresearchcode1114
dc.subject.fieldofresearchcode1117
dc.titleThe effect of pregnancy-induced hypertensive disorders on placental growth along short and long axes and neonatal outcomes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorEllwood, David


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