dc.contributor.author | Phad, Neelkanth | |
dc.contributor.author | Dahlstrom, Jane E | |
dc.contributor.author | Ellwood, David | |
dc.contributor.author | Kent, Alison L | |
dc.date.accessioned | 2018-09-21T01:00:37Z | |
dc.date.available | 2018-09-21T01:00:37Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0004-8666 | |
dc.identifier.doi | 10.1111/ajo.12308 | |
dc.identifier.uri | http://hdl.handle.net/10072/141793 | |
dc.description.abstract | Aim: To assess the effect of pregnancy-induced hypertensive disorders on the growth of the placenta on the short and
long axes and neonatal outcomes.
Materials and Methods: A retrospective cohort study of gross and histological characteristics of placentas and the fetal
outcomes of normotensive and hypertensive pregnancies over a three-year period from January 2009 to December 2011 at
a tertiary teaching hospital in ACT, Australia.
Results: Placentas and neonatal outcomes from 100 pregnancies complicated with pregnancy-induced hypertension/preeclampsia
were studied and compared with 51 gestational age-matched placentas and neonatal outcomes from
normotensive pregnancies. The median maternal age and smoking history were similar in the two groups (P = 0.894;
P = 1.00, respectively). The median pre-pregnancy weight was significantly higher (P < 0.001) and primiparity more
common (P = 0.001) in the study group. The median weight of the placenta was significantly lower (P < 0.001) and
below the 10th centile (P < 0.001) in the study group. Both the long and short axes of the placental disc were significantly
smaller in the study group (P = 0.002; P ≤ 0.001 respectively). Accelerated villous maturation, placental infarcts and
decidual vessel vasculopathy were more common in the study group (P < 0.001). The median birthweight and the
number of infants with birthweight and length below the 10th centile were significantly higher in the study group
(P = 0.008; P < 0.001; P = 0.004, respectively).
Conclusion: This study demonstrates that pregnancy-induced hypertension significantly influences the growth and
development of both the placenta and fetus | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Wiley-Blackwell Publishing Asia | |
dc.publisher.place | Australia | |
dc.relation.ispartofpagefrom | 239 | |
dc.relation.ispartofpageto | 244 | |
dc.relation.ispartofissue | 3 | |
dc.relation.ispartofjournal | Australian and New Zealand Journal of Obstetrics and Gynaecology | |
dc.relation.ispartofvolume | 55 | |
dc.subject.fieldofresearch | Medical and Health Sciences not elsewhere classified | |
dc.subject.fieldofresearch | Paediatrics and Reproductive Medicine | |
dc.subject.fieldofresearch | Public Health and Health Services | |
dc.subject.fieldofresearchcode | 119999 | |
dc.subject.fieldofresearchcode | 1114 | |
dc.subject.fieldofresearchcode | 1117 | |
dc.title | The effect of pregnancy-induced hypertensive disorders on placental growth along short and long axes and neonatal outcomes | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Ellwood, David | |