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dc.contributor.authorWest, Nicen_US
dc.contributor.authorB. Pyne, Daviden_US
dc.contributor.authorRenshaw, Gillianen_US
dc.contributor.authorCripps, Allanen_US
dc.contributor.editorAlex van Belkumen_US
dc.date.accessioned2017-04-24T11:47:37Z
dc.date.available2017-04-24T11:47:37Z
dc.date.issued2006en_US
dc.date.modified2009-09-24T05:55:54Z
dc.identifier.issn09288244en_US
dc.identifier.doi10.1111/j.1574-695X.2006.00132.xen_AU
dc.identifier.urihttp://hdl.handle.net/10072/14185
dc.description.abstractRecombinant exotoxin A (rEPA) from Pseudomonas aeruginosa conjugated to Vibrio cholerae O1 serotype-specific polysaccharides (mono-, di- and hexasaccharide) were immunogenic in mice. Monosaccharide conjugates boosted the humoral responses to the hexasaccharide conjugates. Prior exposure to purified Ogawa lipopolysaccharide (LPS) enabled contra-serotype hexasaccharide conjugates to boost the vibriocidal response, but Inaba LPS did not prime for an enhanced vibriocidal response by a contra-serotype conjugate. Prior exposure to the carrier, and priming B cells with the LPS of either serotype, resulted in enhanced vibriocidal titers if the Ogawa hexasaccharides were used, but a diminished response to the Inaba LPS. These studies demonstrate that the 'functional' B cell epitopes on the LPS differ from those of the neoglycoconjugates and that the order of immunization and the serotype of the boosting conjugate can influence the epitope specificity and function of the antisera.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent1900471 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevier BVen_US
dc.publisher.placeNetherlandsen_US
dc.publisher.urihttp://www.wiley.com/bw/journal.asp?ref=0928-8244en_AU
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom293en_US
dc.relation.ispartofpageto304en_US
dc.relation.ispartofjournalFEMS Immunology and Medical Microbiologyen_US
dc.relation.ispartofvolume48en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode329999en_US
dc.titleAntimicrobial peptides, exercise and innate mucosal immunityen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Allied Health Sciencesen_US
gro.rights.copyrightCopyright 2006 Elsevier. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.en_AU
gro.date.issued2006
gro.hasfulltextFull Text


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