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dc.contributor.authorPlatts, David G
dc.contributor.authorDiab, Sara
dc.contributor.authorDunster, Kimble R
dc.contributor.authorShekar, Kiran
dc.contributor.authorBurstow, Darryl J
dc.contributor.authorSim, Beatrice
dc.contributor.authorTunbridge, Matthew
dc.contributor.authorMcDonald, Charles
dc.contributor.authorChemonges, Saul
dc.contributor.authorChan, Jonathan
dc.contributor.authorFraser, John F
dc.date.accessioned2018-10-09T02:14:42Z
dc.date.available2018-10-09T02:14:42Z
dc.date.issued2015
dc.identifier.issn0742-2822
dc.identifier.doi10.1111/echo.12695
dc.identifier.urihttp://hdl.handle.net/10072/141893
dc.description.abstractBackground: Transthoracic echocardiography (TTE) during extra corporeal membrane oxygenation (ECMO) is important but can be technically challenging. Contrast-specific TTE can improve imaging in suboptimal studies. These contrast microspheres are hydrodynamically labile structures. This study assessed the feasibility of contrast echocardiography (CE) during venovenous (VV) ECMO in a validated ovine model. Method: Twenty-four sheep were commenced on VV ECMO. Parasternal long-axis (Plax) and short-axis (Psax) views were obtained pre- and postcontrast while on VV ECMO. Endocardial definition scores (EDS) per segment were graded: 1 = good, 2 = suboptimal 3 = not seen. Endocardial border definition score index (EBDSI) was calculated for each view. Endocardial length (EL) in the Plax view for the left ventricle (LV) and right ventricle (RV) was measured. Results: Summation EDS data for the LV and RV for unenhanced TTE (UE) versus CE TTE imaging: EDS 1 = 289 versus 346, EDS 2 = 38 versus 10, EDS 3 = 33 versus 4, respectively. Wilcoxon matched-pairs rank-sign tests showed a significant ranking difference (improvement) pre- and postcontrast for the LV (P < 0.0001), RV (P < 0.0001) and combined ventricular data (P < 0.0001). EBDSI for CE TTE was significantly lower than UE TTE for the LV (1.05 0.17 vs. 1.22 0.38, P = 0.0004) and RV (1.06 0.22 vs. 1.42 0.47, P = 0.0.0006) respectively. Visualized EL was significantly longer in CE versus UE for both the LV (58.6 11.0 mm vs. 47.4 11.7 mm, P < 0.0001) and the RV (52.3 8.6 mm vs. 36.0 13.1 mm, P < 0.0001), respectively. Conclusions: Despite exposure to destructive hydrodynamic forces, CE is a feasible technique in an ovine ECMO model. CE results in significantly improved EDS and increased EL. (Echocardiography 2015;32:548–556)
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing, Inc.
dc.relation.ispartofpagefrom548
dc.relation.ispartofpageto556
dc.relation.ispartofissue3
dc.relation.ispartofjournalEchocardiography
dc.relation.ispartofvolume32
dc.subject.fieldofresearchPublic Health and Health Services not elsewhere classified
dc.subject.fieldofresearchCardiorespiratory Medicine and Haematology
dc.subject.fieldofresearchcode111799
dc.subject.fieldofresearchcode1102
dc.titleFeasibility of Perflutren Microsphere Contrast Transthoracic Echocardiography in the Visualization of Ventricular Endocardium during Venovenous Extracorporeal Membrane Oxygenation in a Validated Ovine Model
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorChan, Jonathan H.
gro.griffith.authorFraser, John F.


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