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dc.contributor.authorKremer, S
dc.contributor.authorRenard, F
dc.contributor.authorAchard, S
dc.contributor.authorLana-Peixoto, MA
dc.contributor.authorPalace, J
dc.contributor.authorAsgari, N
dc.contributor.authorKlawiter, EC
dc.contributor.authorTenembaum, SN
dc.contributor.authorBanwell, B
dc.contributor.authorGreenberg, BM
dc.contributor.authorBennett, JL
dc.contributor.authorLevy, M
dc.contributor.authorVilloslada, P
dc.contributor.authorSaiz, A
dc.contributor.authorFujihara, K
dc.contributor.authorChan, KH
dc.contributor.authorSchippling, S
dc.contributor.authorPaul, F
dc.contributor.authorKim, HJ
dc.contributor.authorDe Seze, J
dc.contributor.authorWuerfel, JT
dc.contributor.authorCabre, P
dc.contributor.authorMarignier, R
dc.contributor.authorTedder, T
dc.contributor.authorVan Pelt, D
dc.contributor.authorBroadley, S
dc.contributor.authorChitnis, T
dc.contributor.authorWingerchuk, D
dc.contributor.authorPandit, L
dc.contributor.authorLeite, MI
dc.contributor.authorApiwattanakul, M
dc.contributor.authorKleiter, I
dc.contributor.authorPrayoonwiwat, N
dc.contributor.authorHan, M
dc.contributor.authorHellwig, K
dc.contributor.authorVan Herle, K
dc.contributor.authorJohn, G
dc.contributor.authorHooper, DC
dc.contributor.authorNakashima, I
dc.contributor.authorSato, D
dc.contributor.authorYeaman, MR
dc.contributor.authorWaubant, E
dc.contributor.authorZamvil, S
dc.contributor.authorStüve, O
dc.contributor.authorAktas, O
dc.contributor.authorSmith, TJ
dc.contributor.authorJacob, A
dc.contributor.authorO'Connor, K
dc.date.accessioned2019-02-07T00:33:48Z
dc.date.available2019-02-07T00:33:48Z
dc.date.issued2015
dc.identifier.issn2168-6149
dc.identifier.doi10.1001/jamaneurol.2015.0248
dc.identifier.urihttp://hdl.handle.net/10072/141916
dc.description.abstractBrain parenchymal lesions are frequently observed on conventional magnetic resonance imaging (MRI) scans of patients with neuromyelitis optica (NMO) spectrum disorder, but the specific morphological and temporal patterns distinguishing them unequivocally from lesions caused by other disorders have not been identified. This literature review summarizes the literature on advanced quantitative imaging measures reported for patients with NMO spectrum disorder, including proton MR spectroscopy, diffusion tensor imaging, magnetization transfer imaging, quantitative MR volumetry, and ultrahigh-field strength MRI. It was undertaken to consider the advanced MRI techniques used for patients with NMO by different specialists in the field. Although quantitative measures such as proton MR spectroscopy or magnetization transfer imaging have not reproducibly revealed diffuse brain injury, preliminary data from diffusion-weighted imaging and brain tissue volumetry indicate greater white matter than gray matter degradation. These findings could be confirmed by ultrahigh-field MRI. The use of nonconventional MRI techniques may further our understanding of the pathogenic processes in NMO spectrum disorders and may help us identify the distinct radiographic features corresponding to specific phenotypic manifestations of this disease.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherAmerican Medical Association
dc.relation.ispartofpagefrom815
dc.relation.ispartofpageto822
dc.relation.ispartofissue7
dc.relation.ispartofjournalJAMA Neurology
dc.relation.ispartofvolume72
dc.subject.fieldofresearchClinical Sciences not elsewhere classified
dc.subject.fieldofresearchcode110399
dc.titleUse of Advanced Magnetic Resonance Imaging Techniques in Neuromyelitis Optica Spectrum Disorder
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionPost-print
gro.rights.copyright© 2015 American Medical Association (AMA). This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
gro.hasfulltextFull Text
gro.griffith.authorBroadley, Simon


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