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dc.contributor.authorKremer, Stephane
dc.contributor.authorRenard, Felix
dc.contributor.authorAchard, Sophie
dc.contributor.authorLana-Peixoto, Marco A.
dc.contributor.authorPalace, Jacqueline
dc.contributor.authorAsgari, Nasrin
dc.contributor.authorKlawiter, Eric C.
dc.contributor.authorKlawiter, Eric C.
dc.contributor.authorTenembaum, Silvia N.
dc.contributor.authorBanwell, Brenda
dc.contributor.authorGreenberg, Benjamin M.
dc.contributor.authorBennett, Jeffrey L.
dc.contributor.authorLevy, Michael
dc.contributor.authorVilloslada, Pablo
dc.contributor.authorSaiz, Albert
dc.contributor.authorFujihara, Kazuo
dc.contributor.authorChan, Koon Ho
dc.contributor.authorSchippling, Sven
dc.contributor.authorPaul, Friedemann
dc.contributor.authorKim, Ho Jin
dc.contributor.authorSeze, Jerome de
dc.contributor.authorWuerfe, Jens T.
dc.contributor.authorBroadley, Simon
dc.date.accessioned2019-02-07T00:33:48Z
dc.date.available2019-02-07T00:33:48Z
dc.date.issued2015
dc.identifier.issn2168-6149en_US
dc.identifier.doi10.1001/jamaneurol.2015.0248en_US
dc.identifier.urihttp://hdl.handle.net/10072/141916
dc.description.abstractBrain parenchymal lesions are frequently observed on conventional magnetic resonance imaging (MRI) scans of patients with neuromyelitis optica (NMO) spectrum disorder, but the specific morphological and temporal patterns distinguishing them unequivocally from lesions caused by other disorders have not been identified. This literature review summarizes the literature on advanced quantitative imaging measures reported for patients with NMO spectrum disorder, including proton MR spectroscopy, diffusion tensor imaging, magnetization transfer imaging, quantitative MR volumetry, and ultrahigh-field strength MRI. It was undertaken to consider the advanced MRI techniques used for patients with NMO by different specialists in the field. Although quantitative measures such as proton MR spectroscopy or magnetization transfer imaging have not reproducibly revealed diffuse brain injury, preliminary data from diffusion-weighted imaging and brain tissue volumetry indicate greater white matter than gray matter degradation. These findings could be confirmed by ultrahigh-field MRI. The use of nonconventional MRI techniques may further our understanding of the pathogenic processes in NMO spectrum disorders and may help us identify the distinct radiographic features corresponding to specific phenotypic manifestations of this disease.en_US
dc.description.peerreviewedYesen_US
dc.languageenglishen_US
dc.publisherAmerican Medical Associationen_US
dc.relation.ispartofpagefrom815en_US
dc.relation.ispartofpageto822en_US
dc.relation.ispartofissue7en_US
dc.relation.ispartofjournalJAMA Neurologyen_US
dc.relation.ispartofvolume72en_US
dc.subject.fieldofresearchClinical Sciences not elsewhere classifieden_US
dc.subject.fieldofresearchcode110399en_US
dc.titleUse of Advanced Magnetic Resonance Imaging Techniques in Neuromyelitis Optica Spectrum Disorderen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
dc.description.versionPost-printen_US
gro.rights.copyright© 2015 American Medical Association (AMA). This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.en_US
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