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  • Pseudomonas aeruginosa genotypes acquired by children with cystic fibrosis by age 5-years

    Author(s)
    Kidd, Timothy J
    Ramsay, Kay A
    Vidmar, Suzanna
    Carlin, John B
    Bell, Scott C
    Wainwright, Claire E
    Grimwood, Keith
    Wainwright, Claire E
    Grimwood, Keith
    Francis, Paul W
    Dakin, Carolyn
    Cheney, Joyce
    George, Narelle
    Carlin, John B
    Robertson, Colin F
    Vidmar, Suzanna
    Moodie, Marj
    Carzino, Rosemary
    Carter, Robert
    Armstrong, David S
    Cooper, Peter J
    Mckay, Karen
    Martin, A James
    Whitehead, Bruce
    Hunter, John
    By-Rnes, Catherine A
    Tiddens, Harm A
    Graniel, Karla
    Gerbrands, Krista
    Mott, Lauren
    Griffith University Author(s)
    Grimwood, Keith
    Year published
    2015
    Metadata
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    Abstract
    Background: We describe Pseudomonas aeruginosa acquisitions in children with cystic fibrosis (CF) aged ≤5-years, eradication treatment efficacy, and genotypic relationships between upper and lower airway isolates and strains from non-CF sources. Methods: Of 168 CF children aged ≤5-years in a bronchoalveolar lavage (BAL)-directed therapy trial, 155 had detailed microbiological results. Overall, 201/271 (74%) P. aeruginosa isolates from BAL and oropharyngeal cultures were available for genotyping, including those collected before and after eradication therapy. Results: Eighty-two (53%) subjects acquired P. aeruginosa, of which ...
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    Background: We describe Pseudomonas aeruginosa acquisitions in children with cystic fibrosis (CF) aged ≤5-years, eradication treatment efficacy, and genotypic relationships between upper and lower airway isolates and strains from non-CF sources. Methods: Of 168 CF children aged ≤5-years in a bronchoalveolar lavage (BAL)-directed therapy trial, 155 had detailed microbiological results. Overall, 201/271 (74%) P. aeruginosa isolates from BAL and oropharyngeal cultures were available for genotyping, including those collected before and after eradication therapy. Results: Eighty-two (53%) subjects acquired P. aeruginosa, of which most were unique strains. Initial eradication success rate was 90%, but 36 (44%) reacquired P. aeruginosa, with genotypic substitutions more common in BAL (12/14) than oropharyngeal (3/11) cultures. Moreover, oropharyngeal cultures did not predict BAL genotypes reliably. Conclusions: CF children acquire environmental P. aeruginosa strains frequently. However, discordance between BAL and oropharyngeal strains raises questions over upper airway reservoirs and how to best determine eradication in non-expectorating children.
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    Journal Title
    Journal of Cystic Fibrosis
    Volume
    14
    Issue
    3
    DOI
    https://doi.org/10.1016/j.jcf.2014.12.007
    Subject
    Clinical Sciences not elsewhere classified
    Clinical Sciences
    Publication URI
    http://hdl.handle.net/10072/141920
    Collection
    • Journal articles

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