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dc.contributor.authorScott, Fraser J
dc.contributor.authorKhalaf, Abedawn I
dc.contributor.authorGiordani, Federica
dc.contributor.authorWong, Pui Ee
dc.contributor.authorDuffy, Sandra
dc.contributor.authorBarrett, Michael
dc.contributor.authorAvery, Vicky M
dc.contributor.authorSuckling, Colin J
dc.date.accessioned2019-02-08T01:31:07Z
dc.date.available2019-02-08T01:31:07Z
dc.date.issued2016
dc.identifier.issn0223-5234
dc.identifier.doi10.1016/j.ejmech.2016.03.064
dc.identifier.urihttp://hdl.handle.net/10072/142114
dc.description.abstractA series of 32 structurally diverse MGBs, derived from the natural product distamycin, was evaluated for activity against Trypanosoma brucei brucei. Four compounds have been found to possess significant activity, in the nanomolar range, and represent hits for further optimisation towards novel treatments for Human and Animal African Trypanosomiases. Moreover, SAR indicates that the head group linking moiety is a significant modulator of biological activity.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom116
dc.relation.ispartofpageto125
dc.relation.ispartofjournalEuropean Journal of Medicinal Chemistry
dc.relation.ispartofvolume116
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry not elsewhere classified
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry
dc.subject.fieldofresearchOrganic Chemistry
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode030499
dc.subject.fieldofresearchcode0304
dc.subject.fieldofresearchcode0305
dc.subject.fieldofresearchcode1115
dc.titleAn evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorDuffy, Sandra
gro.griffith.authorAvery, Vicky M.


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