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dc.contributor.authorWilliams, James T
dc.contributor.authorCorcilius, Leo
dc.contributor.authorKiefel, Milton J
dc.contributor.authorPayne, Richard J
dc.date.accessioned2018-01-24T00:57:56Z
dc.date.available2018-01-24T00:57:56Z
dc.date.issued2016
dc.identifier.issn0022-3263
dc.identifier.doi10.1021/acs.joc.5b02754
dc.identifier.urihttp://hdl.handle.net/10072/142211
dc.description.abstractThe pseudaminic acids are a family of 5,7-diamino-3,5,7,9-tetradeoxynonulosonic acids that are functional components of flagellin and pili proteins within clinically relevant Gram-negative bacteria. Herein, we describe the total synthesis of the most common pseudaminic acid, 5,7-diacetylpseudaminic acid, from N-acetylneuraminic acid. The divergent nature of the route reported here provides a robust and versatile means to access other members of the family, together with analogues, for probing the functional role of the pseudaminic acids and pseudaminic acid derived proteins in the future.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.ispartofpagefrom2607
dc.relation.ispartofpageto2611
dc.relation.ispartofissue6
dc.relation.ispartofjournalJournal of Organic Chemistry
dc.relation.ispartofvolume81
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchOrganic chemistry
dc.subject.fieldofresearchOrganic chemistry not elsewhere classified
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3405
dc.subject.fieldofresearchcode340599
dc.titleTotal Synthesis of Native 5,7-Diacetylpseudaminic Acid from N-Acetylneuraminic Acid
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.rights.copyright© 2016 American Chemical Society
gro.hasfulltextFull Text
gro.griffith.authorKiefel, Milton


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