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dc.contributor.authorVernon, LT
dc.contributor.authorJayashantha, PLP
dc.contributor.authorChidzonga, MM
dc.contributor.authorKomesu, MC
dc.contributor.authorNair, RG
dc.contributor.authorJohnson, NW
dc.date.accessioned2018-07-25T04:54:45Z
dc.date.available2018-07-25T04:54:45Z
dc.date.issued2016
dc.identifier.issn1354-523X
dc.identifier.doi10.1111/odi.12412
dc.identifier.urihttp://hdl.handle.net/10072/142214
dc.description.abstractIn the era of combination antiretroviral therapy (ART), parsing out the effects of HIV vs ART on health outcomes is challenging. Nadir CD4 count, a marker of the extent of immunosuppression, has significant long‐term impact on an array of disease states in HIV+ persons; however, in the dental literature, reporting of pre‐ART exposure to immunosuppression has largely been ignored and this limits the validity of previous studies. In Workshop A1, we explain fully the importance of nadir CD4, pre‐ART immunosuppression, and identify a need to include specific variables in future research. The questions posed herein are challenging, typically not neatly addressed by any one study and require integration of the latest evidence from the wider medical literature. We consider topics beyond the confines of the oral cavity and examine oral health in the complex context of ART era HIV immunopathophysiology. We depict how variability in geographic setting and time period (pre‐ and post‐ART era) can impact oral conditions – influencing when HIV infection was detected (at what CD4 count), the type and timing of ART as well as social determinants such as strong stigma and limited access to care. We hope our Workshop will stir debate and energize a rigorous focus on relevant areas of future research in HIV/AIDS.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing, Inc.
dc.relation.ispartofpagefrom135
dc.relation.ispartofpageto148
dc.relation.ispartofissueSuppl. 1
dc.relation.ispartofjournalOral Diseases
dc.relation.ispartofvolume22
dc.subject.fieldofresearchDentistry not elsewhere classified
dc.subject.fieldofresearchDentistry
dc.subject.fieldofresearchcode110599
dc.subject.fieldofresearchcode1105
dc.titleComorbidities associated with HIV and antiretroviral therapy (clinical sciences): a workshop report
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorJohnson, Newell W.
gro.griffith.authorNair, Raj
gro.griffith.authorJayashantha, Pradeep Jayashantha P.


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