Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes
Author(s)
Mackay, Laura K
Minnich, Martina
Kragten, Natasja AM
Liao, Yang
Nota, Benjamin
Seillet, Cyril
Zaid, Ali
Man, Kevin
Preston, Simon
Freestone, David
Braun, Asolina
Wynne-Jones, Erica
Behr, Felix M
Stark, Regina
Pellicci, Daniel G
Godfrey, Dale I
Belz, Gabrielle T
Pellegrini, Marc
Gebhardt, Thomas
Busslinger, Meinrad
Shi, Wei
Carbone, Francis R
van Lier, Rene AW
Kallies, Axel
van Gisbergen, Klaas PJM
Griffith University Author(s)
Year published
2016
Metadata
Show full item recordAbstract
Tissue-resident memory T (Trm) cells permanently localize to portals of pathogen entry, where they provide immediate protection against reinfection. To enforce tissue retention, Trm cells up-regulate CD69 and down-regulate molecules associated with tissue egress; however, a Trm-specific transcriptional regulator has not been identified. Here, we show that the transcription factor Hobit is specifically up-regulated in Trm cells and, together with related Blimp1, mediates the development of Trm cells in skin, gut, liver, and kidney in mice. The Hobit-Blimp1 transcriptional module is also required for other populations of ...
View more >Tissue-resident memory T (Trm) cells permanently localize to portals of pathogen entry, where they provide immediate protection against reinfection. To enforce tissue retention, Trm cells up-regulate CD69 and down-regulate molecules associated with tissue egress; however, a Trm-specific transcriptional regulator has not been identified. Here, we show that the transcription factor Hobit is specifically up-regulated in Trm cells and, together with related Blimp1, mediates the development of Trm cells in skin, gut, liver, and kidney in mice. The Hobit-Blimp1 transcriptional module is also required for other populations of tissue-resident lymphocytes, including natural killer T (NKT) cells and liver-resident NK cells, all of which share a common transcriptional program. Our results identify Hobit and Blimp1 as central regulators of this universal program that instructs tissue retention in diverse tissue-resident lymphocyte populations.
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View more >Tissue-resident memory T (Trm) cells permanently localize to portals of pathogen entry, where they provide immediate protection against reinfection. To enforce tissue retention, Trm cells up-regulate CD69 and down-regulate molecules associated with tissue egress; however, a Trm-specific transcriptional regulator has not been identified. Here, we show that the transcription factor Hobit is specifically up-regulated in Trm cells and, together with related Blimp1, mediates the development of Trm cells in skin, gut, liver, and kidney in mice. The Hobit-Blimp1 transcriptional module is also required for other populations of tissue-resident lymphocytes, including natural killer T (NKT) cells and liver-resident NK cells, all of which share a common transcriptional program. Our results identify Hobit and Blimp1 as central regulators of this universal program that instructs tissue retention in diverse tissue-resident lymphocyte populations.
View less >
Journal Title
Science
Volume
352
Issue
6284
Subject
Cellular immunology