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  • Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

    Author(s)
    Mackay, Laura K
    Minnich, Martina
    Kragten, Natasja AM
    Liao, Yang
    Nota, Benjamin
    Seillet, Cyril
    Zaid, Ali
    Man, Kevin
    Preston, Simon
    Freestone, David
    Braun, Asolina
    Wynne-Jones, Erica
    Behr, Felix M
    Stark, Regina
    Pellicci, Daniel G
    Godfrey, Dale I
    Belz, Gabrielle T
    Pellegrini, Marc
    Gebhardt, Thomas
    Busslinger, Meinrad
    Shi, Wei
    Carbone, Francis R
    van Lier, Rene AW
    Kallies, Axel
    van Gisbergen, Klaas PJM
    Griffith University Author(s)
    Zaid, Ali
    Year published
    2016
    Metadata
    Show full item record
    Abstract
    Tissue-resident memory T (Trm) cells permanently localize to portals of pathogen entry, where they provide immediate protection against reinfection. To enforce tissue retention, Trm cells up-regulate CD69 and down-regulate molecules associated with tissue egress; however, a Trm-specific transcriptional regulator has not been identified. Here, we show that the transcription factor Hobit is specifically up-regulated in Trm cells and, together with related Blimp1, mediates the development of Trm cells in skin, gut, liver, and kidney in mice. The Hobit-Blimp1 transcriptional module is also required for other populations of ...
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    Tissue-resident memory T (Trm) cells permanently localize to portals of pathogen entry, where they provide immediate protection against reinfection. To enforce tissue retention, Trm cells up-regulate CD69 and down-regulate molecules associated with tissue egress; however, a Trm-specific transcriptional regulator has not been identified. Here, we show that the transcription factor Hobit is specifically up-regulated in Trm cells and, together with related Blimp1, mediates the development of Trm cells in skin, gut, liver, and kidney in mice. The Hobit-Blimp1 transcriptional module is also required for other populations of tissue-resident lymphocytes, including natural killer T (NKT) cells and liver-resident NK cells, all of which share a common transcriptional program. Our results identify Hobit and Blimp1 as central regulators of this universal program that instructs tissue retention in diverse tissue-resident lymphocyte populations.
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    Journal Title
    Science
    Volume
    352
    Issue
    6284
    DOI
    https://doi.org/10.1126/science.aad2035
    Subject
    Cellular immunology
    Publication URI
    http://hdl.handle.net/10072/142281
    Collection
    • Journal articles

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