dc.contributor.author | Mackay, Laura K | |
dc.contributor.author | Minnich, Martina | |
dc.contributor.author | Kragten, Natasja AM | |
dc.contributor.author | Liao, Yang | |
dc.contributor.author | Nota, Benjamin | |
dc.contributor.author | Seillet, Cyril | |
dc.contributor.author | Zaid, Ali | |
dc.contributor.author | Man, Kevin | |
dc.contributor.author | Preston, Simon | |
dc.contributor.author | Freestone, David | |
dc.contributor.author | Braun, Asolina | |
dc.contributor.author | Wynne-Jones, Erica | |
dc.contributor.author | Behr, Felix M | |
dc.contributor.author | Stark, Regina | |
dc.contributor.author | Pellicci, Daniel G | |
dc.contributor.author | Godfrey, Dale I | |
dc.contributor.author | Belz, Gabrielle T | |
dc.contributor.author | Pellegrini, Marc | |
dc.contributor.author | Gebhardt, Thomas | |
dc.contributor.author | Busslinger, Meinrad | |
dc.contributor.author | Shi, Wei | |
dc.contributor.author | Carbone, Francis R | |
dc.contributor.author | van Lier, Rene AW | |
dc.contributor.author | Kallies, Axel | |
dc.contributor.author | van Gisbergen, Klaas PJM | |
dc.date.accessioned | 2018-07-23T12:30:33Z | |
dc.date.available | 2018-07-23T12:30:33Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0036-8075 | |
dc.identifier.doi | 10.1126/science.aad2035 | |
dc.identifier.uri | http://hdl.handle.net/10072/142281 | |
dc.description.abstract | Tissue-resident memory T (Trm) cells permanently localize to portals of pathogen entry, where they provide immediate protection against reinfection. To enforce tissue retention, Trm cells up-regulate CD69 and down-regulate molecules associated with tissue egress; however, a Trm-specific transcriptional regulator has not been identified. Here, we show that the transcription factor Hobit is specifically up-regulated in Trm cells and, together with related Blimp1, mediates the development of Trm cells in skin, gut, liver, and kidney in mice. The Hobit-Blimp1 transcriptional module is also required for other populations of tissue-resident lymphocytes, including natural killer T (NKT) cells and liver-resident NK cells, all of which share a common transcriptional program. Our results identify Hobit and Blimp1 as central regulators of this universal program that instructs tissue retention in diverse tissue-resident lymphocyte populations. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | American Association for the Advancement of Science | |
dc.relation.ispartofpagefrom | 459 | |
dc.relation.ispartofpageto | 463 | |
dc.relation.ispartofissue | 6284 | |
dc.relation.ispartofjournal | Science | |
dc.relation.ispartofvolume | 352 | |
dc.subject.fieldofresearch | Cellular immunology | |
dc.subject.fieldofresearchcode | 320404 | |
dc.title | Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Zaid, Ali | |