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dc.contributor.authorMackay, Laura K
dc.contributor.authorMinnich, Martina
dc.contributor.authorKragten, Natasja AM
dc.contributor.authorLiao, Yang
dc.contributor.authorNota, Benjamin
dc.contributor.authorSeillet, Cyril
dc.contributor.authorZaid, Ali
dc.contributor.authorMan, Kevin
dc.contributor.authorPreston, Simon
dc.contributor.authorFreestone, David
dc.contributor.authorBraun, Asolina
dc.contributor.authorWynne-Jones, Erica
dc.contributor.authorBehr, Felix M
dc.contributor.authorStark, Regina
dc.contributor.authorPellicci, Daniel G
dc.contributor.authorGodfrey, Dale I
dc.contributor.authorBelz, Gabrielle T
dc.contributor.authorPellegrini, Marc
dc.contributor.authorGebhardt, Thomas
dc.contributor.authorBusslinger, Meinrad
dc.contributor.authorShi, Wei
dc.contributor.authorCarbone, Francis R
dc.contributor.authorvan Lier, Rene AW
dc.contributor.authorKallies, Axel
dc.contributor.authorvan Gisbergen, Klaas PJM
dc.date.accessioned2018-07-23T12:30:33Z
dc.date.available2018-07-23T12:30:33Z
dc.date.issued2016
dc.identifier.issn0036-8075
dc.identifier.doi10.1126/science.aad2035
dc.identifier.urihttp://hdl.handle.net/10072/142281
dc.description.abstractTissue-resident memory T (Trm) cells permanently localize to portals of pathogen entry, where they provide immediate protection against reinfection. To enforce tissue retention, Trm cells up-regulate CD69 and down-regulate molecules associated with tissue egress; however, a Trm-specific transcriptional regulator has not been identified. Here, we show that the transcription factor Hobit is specifically up-regulated in Trm cells and, together with related Blimp1, mediates the development of Trm cells in skin, gut, liver, and kidney in mice. The Hobit-Blimp1 transcriptional module is also required for other populations of tissue-resident lymphocytes, including natural killer T (NKT) cells and liver-resident NK cells, all of which share a common transcriptional program. Our results identify Hobit and Blimp1 as central regulators of this universal program that instructs tissue retention in diverse tissue-resident lymphocyte populations.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Association for the Advancement of Science
dc.relation.ispartofpagefrom459
dc.relation.ispartofpageto463
dc.relation.ispartofissue6284
dc.relation.ispartofjournalScience
dc.relation.ispartofvolume352
dc.subject.fieldofresearchCellular immunology
dc.subject.fieldofresearchcode320404
dc.titleHobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorZaid, Ali


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