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  • Skin CD4+ memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation

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    CollinsPUB2629.pdf (2.774Mb)
    Author(s)
    Collins, Nicholas
    Jiang, Xiaodong
    Zaid, Ali
    Macleod, Bethany L
    Li, Jane
    Park, Chang Ook
    Haque, Ashraful
    Bedoui, Sammy
    Heath, William R
    Mueller, Scott N
    Kupper, Thomas S
    Gebhardt, Thomas
    Carbone, Francis R
    Griffith University Author(s)
    Zaid, Ali
    Year published
    2016
    Metadata
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    Abstract
    Although memory T cells within barrier tissues can persist as permanent residents, at least some exchange with blood. The extent to which this occurs is unclear. Here we show that memory CD4þ T cells in mouse skin are in equilibrium with the circulation at steady state. These cells are dispersed throughout the inter-follicular regions of the dermis and form clusters with antigen presenting cells around hair follicles. After infection or administration of a contact sensitizing agent, there is a sustained increase in skin CD4þ T-cell content, which is confined to the clusters, with a concomitant CCL5-dependent increase in CD4þ ...
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    Although memory T cells within barrier tissues can persist as permanent residents, at least some exchange with blood. The extent to which this occurs is unclear. Here we show that memory CD4þ T cells in mouse skin are in equilibrium with the circulation at steady state. These cells are dispersed throughout the inter-follicular regions of the dermis and form clusters with antigen presenting cells around hair follicles. After infection or administration of a contact sensitizing agent, there is a sustained increase in skin CD4þ T-cell content, which is confined to the clusters, with a concomitant CCL5-dependent increase in CD4þ T-cell recruitment. Skin CCL5 is derived from CD11bþ cells and CD8þ T cells, with the elimination of the latter decreasing CD4þ T-cell numbers. These results reveal a complex pattern of tissue-retention and equilibration for CD4þ memory T cells in skin, which is altered by infection and inflammation history.
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    Journal Title
    Nature Communications
    Volume
    7
    DOI
    https://doi.org/10.1038/ncomms11514
    Copyright Statement
    © The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
    Subject
    Cellular Immunology
    Publication URI
    http://hdl.handle.net/10072/142284
    Collection
    • Journal articles

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