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dc.contributor.authorZaid, Ali
dc.contributor.authorMackay, Laura K
dc.contributor.authorRahimpour, Azad
dc.contributor.authorBraun, Asolina
dc.contributor.authorVeldhoen, Marc
dc.contributor.authorCarbone, Francis R
dc.contributor.authorManton, Jonathan H
dc.contributor.authorHeath, William R
dc.contributor.authorMueller, Scott N
dc.date.accessioned2018-04-29T23:45:18Z
dc.date.available2018-04-29T23:45:18Z
dc.date.issued2014
dc.identifier.issn0027-8424
dc.identifier.doi10.1073/pnas.1322292111
dc.identifier.urihttp://hdl.handle.net/10072/142287
dc.description.abstractBarrier tissues such as the skin contain various populations of immune cells that contribute to protection from infections. These include recently identified tissue-resident memory T cells (TRM). In the skin, these memory CD8+ T cells reside in the epidermis after being recruited to this site by infection or inflammation. In this study, we demonstrate prolonged persistence of epidermal TRM preferentially at the site of prior infection despite sustained migration. Computational simulation of TRM migration within the skin over long periods revealed that the slow rate of random migration effectively constrains these memory cells within the region of skin in which they form. Notably, formation of TRM involved a concomitant local reduction in dendritic epidermal γδ T-cell numbers in the epidermis, indicating that these populations persist in mutual exclusion and may compete for local survival signals. Accordingly, we show that expression of the aryl hydrocarbon receptor, a transcription factor important for dendritic epidermal γδ T-cell maintenance in skin, also contributes to the persistence of skin TRM. Together, these data suggest that skin tissue-resident memory T cells persist within a tightly regulated epidermal T-cell niche.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherNational Academy of Sciences
dc.relation.ispartofpagefrom5307
dc.relation.ispartofpageto5312
dc.relation.ispartofissue14
dc.relation.ispartofjournalProceedings of the National Academy of Sciences of the United States of America
dc.relation.ispartofvolume111
dc.subject.fieldofresearchCellular Immunology
dc.subject.fieldofresearchcode110704
dc.titlePersistence of skin-resident memory T cells within an epidermal niche
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorZaid, Ali


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