dc.contributor.author | Hor, Jyh Liang | |
dc.contributor.author | Whitney, Paul G | |
dc.contributor.author | Zaid, Ali | |
dc.contributor.author | Brooks, Andrew G | |
dc.contributor.author | Heath, William R | |
dc.contributor.author | Mueller, Scott N | |
dc.date.accessioned | 2018-01-04T04:56:45Z | |
dc.date.available | 2018-01-04T04:56:45Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1074-7613 | |
dc.identifier.doi | 10.1016/j.immuni.2015.07.020 | |
dc.identifier.uri | http://hdl.handle.net/10072/142288 | |
dc.description.abstract | The dynamics of when and where CD4+ T cells provide help for CD8+ T cell priming and which dendritic cells (DCs) activate CD4+ T cells in vivo after localized infection are poorly understood. By using a cutaneous herpes simplex virus infection model combined with intravital 2-photon imaging of the draining lymph node (LN) to concurrently visualize pathogen-specific CD4+ and CD8+ T cells, we found that early priming of CD4+ T cells involved clustering with migratory skin DCs. CD8+ T cells did not interact with migratory DCs and their activation was delayed, requiring later clustering interactions with LN-resident XCR1+ DCs. CD4+ T cells interacted with these late CD8+ T cell clusters on resident XCR1+ DCs. Together, these data reveal asynchronous T cell activation by distinct DC subsets and highlight the key role of XCR1+ DCs as the central platform for cytotoxic T lymphocyte activation and the delivery of CD4+ T cell help. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Cell Press | |
dc.relation.ispartofpagefrom | 554 | |
dc.relation.ispartofpageto | 565 | |
dc.relation.ispartofissue | 3 | |
dc.relation.ispartofjournal | Immunity | |
dc.relation.ispartofvolume | 43 | |
dc.subject.fieldofresearch | Immunology | |
dc.subject.fieldofresearch | Cellular immunology | |
dc.subject.fieldofresearchcode | 3204 | |
dc.subject.fieldofresearchcode | 320404 | |
dc.title | Spatiotemporally Distinct Interactions with Dendritic Cell Subsets Facilitates CD4+ and CD8+ T Cell Activation to Localized Viral Infection | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Zaid, Ali | |