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dc.contributor.authorHor, Jyh Liang
dc.contributor.authorWhitney, Paul G
dc.contributor.authorZaid, Ali
dc.contributor.authorBrooks, Andrew G
dc.contributor.authorHeath, William R
dc.contributor.authorMueller, Scott N
dc.date.accessioned2018-01-04T04:56:45Z
dc.date.available2018-01-04T04:56:45Z
dc.date.issued2015
dc.identifier.issn1074-7613
dc.identifier.doi10.1016/j.immuni.2015.07.020
dc.identifier.urihttp://hdl.handle.net/10072/142288
dc.description.abstractThe dynamics of when and where CD4+ T cells provide help for CD8+ T cell priming and which dendritic cells (DCs) activate CD4+ T cells in vivo after localized infection are poorly understood. By using a cutaneous herpes simplex virus infection model combined with intravital 2-photon imaging of the draining lymph node (LN) to concurrently visualize pathogen-specific CD4+ and CD8+ T cells, we found that early priming of CD4+ T cells involved clustering with migratory skin DCs. CD8+ T cells did not interact with migratory DCs and their activation was delayed, requiring later clustering interactions with LN-resident XCR1+ DCs. CD4+ T cells interacted with these late CD8+ T cell clusters on resident XCR1+ DCs. Together, these data reveal asynchronous T cell activation by distinct DC subsets and highlight the key role of XCR1+ DCs as the central platform for cytotoxic T lymphocyte activation and the delivery of CD4+ T cell help.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherCell Press
dc.relation.ispartofpagefrom554
dc.relation.ispartofpageto565
dc.relation.ispartofissue3
dc.relation.ispartofjournalImmunity
dc.relation.ispartofvolume43
dc.subject.fieldofresearchCellular Immunology
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchcode110704
dc.subject.fieldofresearchcode1107
dc.titleSpatiotemporally Distinct Interactions with Dendritic Cell Subsets Facilitates CD4+ and CD8+ T Cell Activation to Localized Viral Infection
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorZaid, Ali


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