Titania nanotubes for orchestrating osteogenesis at the bone–implant interface
Author(s)
Gulati, Karan
Maher, Shaheer
Findlay, David M
Losic, Dusan
Griffith University Author(s)
Year published
2016
Metadata
Show full item recordAbstract
Titanium implants can fail due to inappropriate biomechanics at the bone–implant interface that leads to suboptimal osseointegration. Titania nanotubes (TNTs) fabricated on Ti implants by the electrochemical process have emerged as a promising modification strategy to facilitate osseointegration. TNTs enable augmentation of bone cell functions at the bone–implant interface and can be tailored to incorporate multiple functionalities including the loading of active biomolecules into the nanotubes to target anabolic processes in bone conditions such as osteoporotic fractures. Advanced functions can be introduced, including ...
View more >Titanium implants can fail due to inappropriate biomechanics at the bone–implant interface that leads to suboptimal osseointegration. Titania nanotubes (TNTs) fabricated on Ti implants by the electrochemical process have emerged as a promising modification strategy to facilitate osseointegration. TNTs enable augmentation of bone cell functions at the bone–implant interface and can be tailored to incorporate multiple functionalities including the loading of active biomolecules into the nanotubes to target anabolic processes in bone conditions such as osteoporotic fractures. Advanced functions can be introduced, including biopolymers, nanoparticles and electrical stimulation to release growth factors in a desired manner. This review describes the application of TNTs for enhancing osteogenesis at the bone–implant interface, as an alternative approach to systemic delivery of therapeutic agents.
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View more >Titanium implants can fail due to inappropriate biomechanics at the bone–implant interface that leads to suboptimal osseointegration. Titania nanotubes (TNTs) fabricated on Ti implants by the electrochemical process have emerged as a promising modification strategy to facilitate osseointegration. TNTs enable augmentation of bone cell functions at the bone–implant interface and can be tailored to incorporate multiple functionalities including the loading of active biomolecules into the nanotubes to target anabolic processes in bone conditions such as osteoporotic fractures. Advanced functions can be introduced, including biopolymers, nanoparticles and electrical stimulation to release growth factors in a desired manner. This review describes the application of TNTs for enhancing osteogenesis at the bone–implant interface, as an alternative approach to systemic delivery of therapeutic agents.
View less >
Journal Title
Nanomedicine
Volume
11
Issue
14
Subject
Physical chemistry
Medical biotechnology
Nanotechnology
Nanomedicine