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dc.contributor.authorBal, AM
dc.contributor.authorCoombs, GW
dc.contributor.authorHolden, MTG
dc.contributor.authorLindsay, JA
dc.contributor.authorNimmo, GR
dc.contributor.authorTattevin, P
dc.contributor.authorSkov, RL
dc.date.accessioned2018-11-05T05:43:35Z
dc.date.available2018-11-05T05:43:35Z
dc.date.issued2016
dc.identifier.issn2213-7165
dc.identifier.doi10.1016/j.jgar.2016.04.004
dc.identifier.urihttp://hdl.handle.net/10072/142345
dc.description.abstractThe evolution of meticillin-resistant Staphylococcus aureus (MRSA) from meticillin-susceptible S. aureus has been a result of the accumulation of genetic elements under selection pressure from antibiotics. The traditional classification of MRSA into healthcare-associated MRSA (HA-MRSA) and community-associated MRSA (CA-MRSA) is no longer relevant as there is significant overlap of identical clones between these groups, with an increasing recognition of human infection caused by livestock-associated MRSA (LA-MRSA). Genomic studies have enabled us to model the epidemiology of MRSA along these lines. In this review, we discuss the clinical relevance of genomic studies, particularly whole-genome sequencing, in the investigation of outbreaks. We also discuss the blurring of each of the three epidemiological groups (HA-MRSA, CA-MRSA and LA-MRSA), demonstrating the limited relevance of this classification.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherElsevier BV
dc.relation.ispartofpagefrom95
dc.relation.ispartofpageto101
dc.relation.ispartofjournalJournal of Global Antimicrobial Resistance
dc.relation.ispartofvolume6
dc.subject.fieldofresearchClinical Sciences not elsewhere classified
dc.subject.fieldofresearchcode110399
dc.titleGenomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated meticillin-resistant Staphylococcus aureus: Blurring of the traditional definitions
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.versionPost-print
gro.rights.copyright© 2016 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorNimmo, Graeme R.


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