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dc.contributor.authorTodorovic, Michael
dc.contributor.authorWood, Stephen A
dc.contributor.authorMellick, George D
dc.date.accessioned2018-03-22T23:43:06Z
dc.date.available2018-03-22T23:43:06Z
dc.date.issued2016
dc.identifier.issn0300-9564
dc.identifier.doi10.1007/s00702-016-1563-0
dc.identifier.urihttp://hdl.handle.net/10072/142347
dc.description.abstractParkinson’s disease (PD) is a complex multifactorial disorder that has been associated with the processes of oxidative stress. In the absence of curative therapies, modification of the neurodegenerative process—including the manipulation of endogenous antioxidant pathways—is the focus of intensive research. Recently, genetic and pharmacological accretion of the transcription factor, and phase II antioxidant ‘master regulator’ Nrf2, has shown to demonstrably mitigate the toxic neuronal effects of parkinsonian agents such as MPP+, rotenone, and hydrogen peroxide in vitro and in vivo. Furthermore, baseline genetic variability in Nrf2-dependant pathways may promote neuronal susceptibility to exogenous agents and correlate with PD onset within certain populations. While contemporary evidence directly implicating Nrf2 in the pathogenesis of PD is not conclusive and likely contingent upon the evaluation of complex interacting factors—including genetic variation and a history of environmental exposures—it remains a promising target for therapeutic benefit in the modulation of oxidative stress.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer-Verlag
dc.relation.ispartofpagefrom611
dc.relation.ispartofpageto619
dc.relation.ispartofissue6
dc.relation.ispartofjournalJournal of Neural Transmission
dc.relation.ispartofvolume123
dc.subject.fieldofresearchPsychology not elsewhere classified
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode170199
dc.subject.fieldofresearchcode1109
dc.subject.fieldofresearchcode1701
dc.titleNrf2: a modulator of Parkinson's disease?
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dc.description.versionAccepted Manuscript (AM)
gro.facultyGriffith Sciences, Griffith Institute for Drug Discovery
gro.rights.copyright© 2016 Springer-Verlag Wien. This is an electronic version of an article published in the Journal of Neural Transmission, Volume 123, Issue 6, pages 611-619, 2016. The Journal of Neural Transmission is available online at: http://link.springer.com/ with the open URL of your article.
gro.hasfulltextFull Text
gro.griffith.authorMellick, George
gro.griffith.authorTodorovic, Michael
gro.griffith.authorWood, Stephen A.


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