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dc.contributor.authorQuilty, MC
dc.contributor.authorKing, AE
dc.contributor.authorGai, W-P
dc.contributor.authorPountney, DL
dc.contributor.authorWest, AK
dc.contributor.authorVickers, JC
dc.contributor.authorDickson, TC
dc.contributor.editorS. Gilman
dc.date.accessioned2017-05-03T15:03:36Z
dc.date.available2017-05-03T15:03:36Z
dc.date.issued2006
dc.date.modified2009-01-13T07:11:08Z
dc.identifier.issn0014-4886
dc.identifier.doi10.1016/j.expneurol.2005.10.018
dc.identifier.urihttp://hdl.handle.net/10072/14236
dc.description.abstractChronic oxidative stress has been linked to the neurodegenerative changes characteristic of Parkinson's disease, particularly alpha-synuclein accumulation and aggregation. However, it remains contentious whether these alpha-synuclein changes are cytotoxic or neuroprotective. The current study utilised long-term primary neural culture techniques with antioxidant free media to study the cellular response to chronic oxidative stress. Cells maintained in antioxidant free media were exquisitely more vulnerable to acute exposure to hydrogen peroxide, yet exposure of up to 10 days in antioxidant free media did not lead to morphological alterations in neurones or glia. However, a subpopulation of neurones demonstrated a significant increase in the level of alpha-synuclein expressed within the cell body and at synaptic sites. This subset of neurones was also more resistant to apoptotic changes following exposure to antioxidant free media relative to other neurones. These data indicate that increased alpha-synuclein content is associated with neuroprotection from relatively low levels of oxidative stress.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeIreland
dc.publisher.urihttp://www.elsevier.com/locate/yexnr
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom249
dc.relation.ispartofpageto256
dc.relation.ispartofedition2006
dc.relation.ispartofissue2
dc.relation.ispartofjournalExperimental Neurology
dc.relation.ispartofvolume199
dc.rights.retentionY
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3209
dc.titleAlpha-synuclein is upregulated in neurones in response to chronic oxidative stress and is associated with neuroprotection
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2006
gro.hasfulltextNo Full Text
gro.griffith.authorPountney, Dean L.


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