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  • The Role of Curcumin Administration in Patients with Major Depressive Disorder: Mini Meta-Analysis of Clinical Trials

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    Author(s)
    Al-Karawi, Dalia
    Al Mamoori, Doaa Alem
    Tayyar, Yaman
    Griffith University Author(s)
    Tayyar, Yaman
    Year published
    2016
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    Abstract
    Major depression is a common, recurrent, and chronic disease that negatively affects the quality of life and increases the risk of mortality. Several studies have demonstrated that curcumin, the yellow‐pigmented substance of the turmeric, possesses antidepressant properties. The aim of this review is to meta‐analytically assess the antidepressant effect of curcumin in patients with major depressive disorders. We extensively searched the literature until August 2015. The random‐effect model was used to calculate the pooled standardized difference of means (SMD). Subgroup analyses were also performed to examine the effect of ...
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    Major depression is a common, recurrent, and chronic disease that negatively affects the quality of life and increases the risk of mortality. Several studies have demonstrated that curcumin, the yellow‐pigmented substance of the turmeric, possesses antidepressant properties. The aim of this review is to meta‐analytically assess the antidepressant effect of curcumin in patients with major depressive disorders. We extensively searched the literature until August 2015. The random‐effect model was used to calculate the pooled standardized difference of means (SMD). Subgroup analyses were also performed to examine the effect of different study characteristics on the overall model. Six clinical trials met the inclusion criteria. Overall, curcumin administration showed a significantly higher reduction in depression symptoms [SMD = −0.34; 95% confidence interval (CI) = −0.56, −0.13; p = 0.002]. Subgroup analyses showed that curcumin had the highest effect when given to middle‐aged patients (SMD = −0.36; 95% CI = −0.59; −0.13; p = 0.002), for longer duration of administration (SMD = −0.40; 95% CI = −0.64, −0.16; p = 0.001), and at higher doses (SMD = −0.36; 95% CI = −0.59, −0.13; p = 0.002). The administration of new formulation of curcumin (BCM‐95) had non‐significantly higher effect on depression as compared with the conventional curcumin–piperine formula. We conclude that there is supporting evidence that curcumin administration reduces depressive symptoms in patients with major depression.
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    Journal Title
    Phytotherapy Research
    Volume
    30
    Issue
    2
    DOI
    https://doi.org/10.1002/ptr.5524
    Copyright Statement
    © 2016 John Wiley & Sons, Ltd. This is the peer reviewed version of the following article: The Role of Curcumin Administration in Patients with Major Depressive Disorder: Mini Meta‐Analysis of Clinical Trials, Phytotherapy Research, Volume 30, Issue 2, February 2016, Pages 175-183, which has been published in final form at 10.1002/ptr.5524. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
    Subject
    Chemical sciences
    Biological sciences
    Biomedical and clinical sciences
    Clinical sciences not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/142370
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    • Journal articles

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