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  • Chemical and Biological Aspects of Marine Sponges from the Family Mycalidae

    Author(s)
    Habener, Leesa J
    Hooper, John NA
    Carroll, Anthony R
    Griffith University Author(s)
    Carroll, Anthony R.
    Year published
    2016
    Metadata
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    Abstract
    Sponges are a useful source of bioactive natural products. Members of the family Mycalidae, in particular, have provided a variety of chemical structures including alkaloids, polyketides, terpene endoperoxides, peptides, and lipids. This review highlights the compounds isolated from Mycalid sponges and their associated biological activities. A diverse group of 190 compounds have been reported from over 40 specimens contained in 49 references. Over half of the studies have reported on the biological activities for the compounds isolated. The polyketides, in particular the macrolides, displayed potent cytotoxic activities ...
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    Sponges are a useful source of bioactive natural products. Members of the family Mycalidae, in particular, have provided a variety of chemical structures including alkaloids, polyketides, terpene endoperoxides, peptides, and lipids. This review highlights the compounds isolated from Mycalid sponges and their associated biological activities. A diverse group of 190 compounds have been reported from over 40 specimens contained in 49 references. Over half of the studies have reported on the biological activities for the compounds isolated. The polyketides, in particular the macrolides, displayed potent cytotoxic activities (< 1 µM), and the alkaloids, in particular the 2,5-disubstituted pyrrole derivatives, were associated with moderate cytotoxic activities (1–20 µM). The pyrrole alkaloids and the cyclic peroxides appear to be phylogenetically restricted to sponges and thus might prove useful when applied to sponge taxonomy. The observed diversity of chemical structures suggests this family makes a good target for targeted biodiscovery projects.
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    Journal Title
    Planta Medica
    Volume
    82
    Issue
    9/10
    DOI
    https://doi.org/10.1055/s-0042-103245
    Subject
    Plant biology
    Plant biology not elsewhere classified
    Traditional, complementary and integrative medicine
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/142371
    Collection
    • Journal articles

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