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dc.contributor.authorJeffery, J
dc.contributor.authorSinha, D
dc.contributor.authorSrihari, S
dc.contributor.authorKalimutho, M
dc.contributor.authorKhanna, KK
dc.date.accessioned2018-11-12T04:25:40Z
dc.date.available2018-11-12T04:25:40Z
dc.date.issued2016
dc.identifier.issn0950-9232
dc.identifier.doi10.1038/onc.2015.128
dc.identifier.urihttp://hdl.handle.net/10072/142415
dc.description.abstractCEP55 was initially identified as a pivotal component of abscission, the final stage of cytokinesis, serving to regulate the physical separation of two daughter cells. Over the past 10 years, several studies have illuminated additional roles for CEP55 including regulating the PI3K/AKT pathway and midbody fate. Concurrently, CEP55 has been studied in the context of cancers including those of the breast, lung, colon and liver. CEP55 overexpression has been found to significantly correlate with tumor stage, aggressiveness, metastasis and poor prognosis across multiple tumor types and therefore has been included as part of several prognostic ‘gene signatures’ for cancer. Here by discussing in depth the functions of CEP55 across different effector pathways, and also its roles as a biomarker and driver of tumorigenesis, we assemble an exhaustive review, thus commemorating a decade of research on CEP55.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofpagefrom683
dc.relation.ispartofpageto690
dc.relation.ispartofjournalOncogene
dc.relation.ispartofvolume35
dc.subject.fieldofresearchOncology and Carcinogenesis not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchcode111299
dc.subject.fieldofresearchcode1103
dc.subject.fieldofresearchcode1112
dc.titleBeyond cytokinesis: The emerging roles of CEP55 in tumorigenesis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorKhanna, Kum K.
gro.griffith.authorSinha, Debottam


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