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  • Linckosides enhance proliferation and induce morphological changes in human olfactory ensheathing cells

    Author(s)
    Velasquez, Johana Tello
    Yao, Rebecca-Qing
    Lim, Filip
    Han, Chunguang
    Ojika, Makoto
    Ekberg, Jenny AK
    Quinn, Ronald J
    St John, James A
    Griffith University Author(s)
    Quinn, Ronald J.
    St John, James A.
    Ekberg, Jenny A.
    Year published
    2016
    Metadata
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    Abstract
    Linckosides are members of the steroid glycoside family isolated from the starfish Linckia laevigata. These natural compounds have notable neuritogenic activity and synergistic effects on NGF-induced neuronal differentiation of PC12 cells. Neurogenic factors or molecules that are able to mimic their activities are known to be involved in the survival, proliferation and migration of neurons and glial cells; however how glial cells respond to specific neurogenic molecules such as linckosides has not been investigated. This study aimed to examine the effect of three different linckosides (linckoside A, B and granulatoside A) ...
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    Linckosides are members of the steroid glycoside family isolated from the starfish Linckia laevigata. These natural compounds have notable neuritogenic activity and synergistic effects on NGF-induced neuronal differentiation of PC12 cells. Neurogenic factors or molecules that are able to mimic their activities are known to be involved in the survival, proliferation and migration of neurons and glial cells; however how glial cells respond to specific neurogenic molecules such as linckosides has not been investigated. This study aimed to examine the effect of three different linckosides (linckoside A, B and granulatoside A) on the morphological properties, proliferation and migration of human olfactory ensheathing cells (hOECs). The proliferation rate after all the treatments was higher than control as detected by MTS assay. Additionally, hOECs displayed dramatic morphological changes characterized by a higher number of processes after linckoside treatment. Interestingly changes in microtubule organization and expression levels of some early neuronal markers (GAP43 and βIII-tubulin) were also observed. An increase in the phosphorylation of ERK 1/2 after addition of the compounds suggests that this pathway may be involved in the linckoside-mediated effects particularly those related to morphological changes. These results are the first description of the stimulating effects of linckosides on hOECs and raise the potential for this natural compound or its derivatives to be used to regulate and enhance the therapeutic properties of OECs, particularly for cell transplantation therapies.
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    Journal Title
    Molecular and Cellular Neuroscience
    Volume
    75
    DOI
    https://doi.org/10.1016/j.mcn.2016.06.005
    Subject
    Neurosciences
    Neurosciences not elsewhere classified
    Psychology
    Cognitive and computational psychology
    Publication URI
    http://hdl.handle.net/10072/142451
    Collection
    • Journal articles

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