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dc.contributor.authorVelasquez, Johana Tello
dc.contributor.authorYao, Rebecca-Qing
dc.contributor.authorLim, Filip
dc.contributor.authorHan, Chunguang
dc.contributor.authorOjika, Makoto
dc.contributor.authorEkberg, Jenny AK
dc.contributor.authorQuinn, Ronald J
dc.contributor.authorSt John, James A
dc.description.abstractLinckosides are members of the steroid glycoside family isolated from the starfish Linckia laevigata. These natural compounds have notable neuritogenic activity and synergistic effects on NGF-induced neuronal differentiation of PC12 cells. Neurogenic factors or molecules that are able to mimic their activities are known to be involved in the survival, proliferation and migration of neurons and glial cells; however how glial cells respond to specific neurogenic molecules such as linckosides has not been investigated. This study aimed to examine the effect of three different linckosides (linckoside A, B and granulatoside A) on the morphological properties, proliferation and migration of human olfactory ensheathing cells (hOECs). The proliferation rate after all the treatments was higher than control as detected by MTS assay. Additionally, hOECs displayed dramatic morphological changes characterized by a higher number of processes after linckoside treatment. Interestingly changes in microtubule organization and expression levels of some early neuronal markers (GAP43 and βIII-tubulin) were also observed. An increase in the phosphorylation of ERK 1/2 after addition of the compounds suggests that this pathway may be involved in the linckoside-mediated effects particularly those related to morphological changes. These results are the first description of the stimulating effects of linckosides on hOECs and raise the potential for this natural compound or its derivatives to be used to regulate and enhance the therapeutic properties of OECs, particularly for cell transplantation therapies.
dc.relation.ispartofjournalMolecular and Cellular Neuroscience
dc.subject.fieldofresearchNeurosciences not elsewhere classified
dc.subject.fieldofresearchCognitive Sciences
dc.titleLinckosides enhance proliferation and induce morphological changes in human olfactory ensheathing cells
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, Griffith Institute for Drug Discovery
gro.hasfulltextNo Full Text
gro.griffith.authorQuinn, Ronald J.
gro.griffith.authorSt John, James A.
gro.griffith.authorEkberg, Jenny A.
gro.griffith.authorTello Velasquez, Johana P.
gro.griffith.authorYao, Rebecca

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