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  • Genomic and immunologic factors associated with viral pathogenesis in a lethal EV71 infected neonatal mouse model

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    Author(s)
    Yue, Yingying
    Li, Peng
    Song, Nannan
    Li, Bingqing
    Li, Zhihui
    Guo, Yuqi
    Zhang, Weidong
    Wei, Ming Q
    Gai, Zhongtao
    Meng, Hong
    Wang, Jiwen
    Qin, Lizeng
    Griffith University Author(s)
    Wei, Ming Q.
    Year published
    2016
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    Abstract
    Hand, foot and mouth disease (HFMD) caused by enterovirus 71 (EV71) has emerged as a major health problem in China and worldwide. The present study aimed to understand the virological features of EV71 and host responses resulting from EV71 infection. Six different EV71 strains were isolated from HFMD patients with severe or mild clinical symptoms, and were analyzed for pathogenicity in vitro and in vivo. The results demonstrated that the six virus strains exhibited similar cytopathogenic effects on susceptible MA104 cells. However, marked differences in histological and immunopathological changes were observed when mice were ...
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    Hand, foot and mouth disease (HFMD) caused by enterovirus 71 (EV71) has emerged as a major health problem in China and worldwide. The present study aimed to understand the virological features of EV71 and host responses resulting from EV71 infection. Six different EV71 strains were isolated from HFMD patients with severe or mild clinical symptoms, and were analyzed for pathogenicity in vitro and in vivo. The results demonstrated that the six virus strains exhibited similar cytopathogenic effects on susceptible MA104 cells. However, marked differences in histological and immunopathological changes were observed when mice were inoculated with the different virus strains. Thus, the viruses studied were divided into two groups, highly or weakly pathogenic. Two representative virus strains, JN200804 and JN200803 (highly and weakly pathogenic, respectively) were studied further to investigate pathogenicity-associated factors, including genetic mutations and immunopathogenesis. The present study has demonstrated that highly pathogenic strains have stable genome and amino acid sequences. Notably, the present study demonstrated that a highly pathogenic strain induced a significant increase of the bulk CD4 T cell levels at 3 days post‑inoculation. In conclusion, the current study demonstrates that genomic and immunologic factors may be responsible for the multiple tissue damage caused by highly pathogenic EV71 infection.
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    Journal Title
    Molecular Medicine Reports
    Volume
    13
    Issue
    5
    DOI
    https://doi.org/10.3892/mmr.2016.5080
    Copyright Statement
    © Yue et al, 2016. This is an open access article distributed under the terms of Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
    Subject
    Biochemistry and Cell Biology not elsewhere classified
    Medicinal and Biomolecular Chemistry
    Biochemistry and Cell Biology
    Publication URI
    http://hdl.handle.net/10072/142452
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    • Journal articles

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