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  • Gray and white matter imaging: A biomarker for cognitive impairment in early Parkinson's disease?

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    Khoo97184-Accepted.pdf (1.338Mb)
    File version
    Accepted Manuscript (AM)
    Author(s)
    Duncan, Gordon W
    Firbank, Michael J
    Yarnall, Alison J
    Khoo, Tien K
    Brooks, David J
    Barker, Roger A
    Burn, David J
    O'Brien, John T
    Griffith University Author(s)
    Khoo, Tien Kheng
    Year published
    2016
    Metadata
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    Abstract
    Background The aim of this work was to investigate the cortical and white matter changes that underlie cognitive impairment in patients with incident Parkinson's disease (PD) disease using voxel-based morphometry and diffusion tensor imaging. Methods Newly diagnosed nondemented PD (n = 125) and control subjects (n = 50) were recruited from the Incidence of Cognitive Impairment in Cohorts with Longitudinal Evaluation in Parkinson's Disease Study and completed cognitive assessments and 3T structural and diffusion tensor MR imaging. Voxel-based morphometry was performed to investigate the relationship between gray matter volume ...
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    Background The aim of this work was to investigate the cortical and white matter changes that underlie cognitive impairment in patients with incident Parkinson's disease (PD) disease using voxel-based morphometry and diffusion tensor imaging. Methods Newly diagnosed nondemented PD (n = 125) and control subjects (n = 50) were recruited from the Incidence of Cognitive Impairment in Cohorts with Longitudinal Evaluation in Parkinson's Disease Study and completed cognitive assessments and 3T structural and diffusion tensor MR imaging. Voxel-based morphometry was performed to investigate the relationship between gray matter volume and cognitive ability. Microstructural white matter changes were assessed with diffusion tensor imaging measures of fractional anisotropy and mean diffusivity using tract-based spatial statistics. Results Increased mean diffusivity was observed bilaterally in subjects with PD, relative to controls (P = 0.019). Increased mean diffusivity was associated with performance on the semantic fluency and Tower of London tasks in frontal and parietal white matter tracts, including the cingulum, superior longitudinal fasciculus, inferior longitudinal fasciculus, and inferior fronto-occipital fasciculus. There was no difference in total gray matter volume between groups; however, bilateral reductions in frontal and parietal gray matter volume were associated with reduced performance on measures of executive function in PD subjects. Conclusions At the earliest stages of PD, regionally specific increases in central white matter mean diffusivity are present and suggest early axonal damage. Such changes are not accompanied by significant gray matter volume loss and are consistent with proposed models of pathological progression of the disease. Structural MRI, especially diffusion tensor imaging analysis, offers potential as a noninvasive biomarker reflecting cognitive impairment in PD. © 2015 International Parkinson and Movement Disorder Society
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    Journal Title
    Movement Disorders
    Volume
    31
    Issue
    1
    DOI
    https://doi.org/10.1002/mds.26312
    Copyright Statement
    © 2016 Movement Disorder Society. This is the pre-peer reviewed version of the following article: Gray and white matter imaging: A biomarker for cognitive impairment in early Parkinson's disease?, Movement Disorders, 31 (3), pp. 103-110, which has been published in final form at https://doi.org/10.1002/mds.26312. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html)
    Subject
    Clinical sciences
    Clinical sciences not elsewhere classified
    Sports science and exercise
    Neurosciences
    Publication URI
    http://hdl.handle.net/10072/142456
    Collection
    • Journal articles

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