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dc.contributor.authorMarasini, Nirmal
dc.contributor.authorGiddam, Ashwini K
dc.contributor.authorGhaffar, Khairunnisa A
dc.contributor.authorBatzloff, Michael R
dc.contributor.authorGood, Michael F
dc.contributor.authorSkwarczynski, Mariusz
dc.contributor.authorToth, Istvan
dc.date.accessioned2018-06-15T07:26:05Z
dc.date.available2018-06-15T07:26:05Z
dc.date.issued2016
dc.identifier.issn1743-5889
dc.identifier.doi10.2217/nnm.16.36
dc.identifier.urihttp://hdl.handle.net/10072/142464
dc.description.abstractAim: To develop an oral nanovaccine delivery system for lipopeptide-based vaccine candidate against group A Streptococcus. Materials & methods: Lipid-core peptide-1-loaded nanoliposomes were prepared as a template and coated with opposite-charged polyelectrolytes to produce particles with size <200 nm. Efficacy of this oral nanovaccine delivery system was evaluated in mice model. Results: Polymer-coated liposomes produced significantly higher antigen-specific mucosal IgA and systemic IgG titers in comparison to vaccine formulated with a strong mucosal adjuvant upon oral immunization in mice. Moreover, high levels of systemic antibody titers were retained even at day 185 postprimary immunization. Conclusion: Efficient oral delivery platform for lipopeptide-based vaccines has been developed.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherFuture Medicine
dc.relation.ispartofpagefrom1223
dc.relation.ispartofpageto1236
dc.relation.ispartofissue10
dc.relation.ispartofjournalNanomedicine
dc.relation.ispartofvolume11
dc.subject.fieldofresearchPhysical chemistry
dc.subject.fieldofresearchMedical biotechnology
dc.subject.fieldofresearchNanotechnology
dc.subject.fieldofresearchNanomedicine
dc.subject.fieldofresearchcode3406
dc.subject.fieldofresearchcode3206
dc.subject.fieldofresearchcode4018
dc.subject.fieldofresearchcode320604
dc.titleMultilayer engineered nanoliposomes as a novel tool for oral delivery of lipopeptide-based vaccines against group A Streptococcus
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorBatzloff, Michael R.
gro.griffith.authorGood, Michael F.


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