dc.contributor.author | Marasini, Nirmal | |
dc.contributor.author | Giddam, Ashwini K | |
dc.contributor.author | Ghaffar, Khairunnisa A | |
dc.contributor.author | Batzloff, Michael R | |
dc.contributor.author | Good, Michael F | |
dc.contributor.author | Skwarczynski, Mariusz | |
dc.contributor.author | Toth, Istvan | |
dc.date.accessioned | 2018-06-15T07:26:05Z | |
dc.date.available | 2018-06-15T07:26:05Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1743-5889 | |
dc.identifier.doi | 10.2217/nnm.16.36 | |
dc.identifier.uri | http://hdl.handle.net/10072/142464 | |
dc.description.abstract | Aim: To develop an oral nanovaccine delivery system for lipopeptide-based vaccine candidate against group A Streptococcus. Materials & methods: Lipid-core peptide-1-loaded nanoliposomes were prepared as a template and coated with opposite-charged polyelectrolytes to produce particles with size <200 nm. Efficacy of this oral nanovaccine delivery system was evaluated in mice model. Results: Polymer-coated liposomes produced significantly higher antigen-specific mucosal IgA and systemic IgG titers in comparison to vaccine formulated with a strong mucosal adjuvant upon oral immunization in mice. Moreover, high levels of systemic antibody titers were retained even at day 185 postprimary immunization. Conclusion: Efficient oral delivery platform for lipopeptide-based vaccines has been developed. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Future Medicine | |
dc.relation.ispartofpagefrom | 1223 | |
dc.relation.ispartofpageto | 1236 | |
dc.relation.ispartofissue | 10 | |
dc.relation.ispartofjournal | Nanomedicine | |
dc.relation.ispartofvolume | 11 | |
dc.subject.fieldofresearch | Physical chemistry | |
dc.subject.fieldofresearch | Medical biotechnology | |
dc.subject.fieldofresearch | Nanotechnology | |
dc.subject.fieldofresearch | Nanomedicine | |
dc.subject.fieldofresearchcode | 3406 | |
dc.subject.fieldofresearchcode | 3206 | |
dc.subject.fieldofresearchcode | 4018 | |
dc.subject.fieldofresearchcode | 320604 | |
dc.title | Multilayer engineered nanoliposomes as a novel tool for oral delivery of lipopeptide-based vaccines against group A Streptococcus | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Good, Michael F. | |