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dc.contributor.authorVelasquez, J Tello
dc.contributor.authorNazareth, L
dc.contributor.authorQuinn, RJ
dc.contributor.authorEkberg, JAK
dc.contributor.authorSt John, JA
dc.date.accessioned2017-11-28T02:59:50Z
dc.date.available2017-11-28T02:59:50Z
dc.date.issued2016
dc.identifier.issn0306-4522
dc.identifier.doi10.1016/j.neuroscience.2016.02.073
dc.identifier.urihttp://hdl.handle.net/10072/142478
dc.description.abstractTransplantation of peripheral glia is being trialled for neural repair therapies, and identification of compounds that enhance the activity of glia is therefore of therapeutic interest. We have previously shown that curcumin potently stimulates the activity of olfactory glia. We have now examined the effect of curcumin on Schwann cell (SC) activities including proliferation, migration and the expression of protein markers. SCs were treated with control media and with different concentrations of curcumin (0.02–20 μM). Cell proliferation was determined by MTS assay and migration changes were determined by single live cell migration tracking. We found that small doses of curcumin (40 nM) dramatically increased the proliferation and migration in SCs within just one day. When compared with olfactory glia, curcumin stimulated SC proliferation more rapidly and at lower concentrations. Curcumin significantly increased the migration of SCs, and also increased the dynamic activity of lamellipodial waves which are essential for SC migration. Expression of the activated form of the MAP kinase p38 (p-p38) was significantly decreased in curcumin-treated SCs. These results show that curcumin’s effects on SCs differ remarkably to its effects on olfactory glia, suggesting that subtypes of closely related glia can be differentially stimulated by curcumin. Overall these results demonstrate that the therapeutically beneficial activities of glia can be differentially enhanced by curcumin which could be used to improve outcomes of neural repair therapies.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom140
dc.relation.ispartofpageto150
dc.relation.ispartofissue2
dc.relation.ispartofjournalNeuroscience
dc.relation.ispartofvolume324
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchNeurosciences not elsewhere classified
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchCognitive and computational psychology
dc.subject.fieldofresearchBiological psychology
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode320999
dc.subject.fieldofresearchcode52
dc.subject.fieldofresearchcode5204
dc.subject.fieldofresearchcode5202
dc.titleStimulating the proliferation, migration and lamellipodia of Schwann cells using low-dose curcumin
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, Griffith Institute for Drug Discovery
gro.hasfulltextNo Full Text
gro.griffith.authorQuinn, Ronald J.
gro.griffith.authorSt John, James A.
gro.griffith.authorEkberg, Jenny A.


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