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dc.contributor.authorCao, Yanjing
dc.contributor.authorGou, Zengmei
dc.contributor.authorDu, Yifeng
dc.contributor.authorFan, Yongjun
dc.contributor.authorLiang, Lizhen
dc.contributor.authorYan, Yongxing
dc.contributor.authorLin, Ping
dc.contributor.authorJin, Mudan
dc.contributor.authorDu, Yifenf
dc.date.accessioned2019-03-08T00:10:34Z
dc.date.available2019-03-08T00:10:34Z
dc.date.issued2016
dc.identifier.issn1872-7972
dc.identifier.doi10.1016/j.neulet.2016.03.039
dc.identifier.urihttp://hdl.handle.net/10072/142479
dc.description.abstractChronic cerebral ischemia (CCI) is associated with cognitive decline in aging, vascular dementia and Alzheimer’s disease. Substantial evidence has shown that chronic cerebral ischemia may cause cognitive impairment, but the underlying neurobiological mechanism is poorly understood so far. In the present study, we used a rat model of chronic cerebral ischemia by permanent bilateral common carotid artery occlusion (BCCAO) to investigate the alterations of glutamatergic and central cholinergic dysfunction, and their causal relationship with the cognitive deficits induced by chronic cerebral ischemia. We found that BCCAO rats exhibited spatial learning and memory impairments dysfunction 3 month after BCCAO. Meanwhile, vGluT levels as well as glutamatergic and central cholinergic positive neurons in the hippocampus CA1-3 field significantly decreased. The protection of glutamergic and cholinergic neurons or regulating glutamate and central cholinergic levels in hippocampal subregion may have beneficial effects on cognitive impairments associated with the possible mechanism in CCI-induced vascular dementia.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherElsevier Ireland
dc.relation.ispartofpagefrom169
dc.relation.ispartofpageto176
dc.relation.ispartofjournalNeuroscience Letters
dc.relation.ispartofvolume620
dc.subject.fieldofresearchNeurosciences not elsewhere classified
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchCognitive Sciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchcode110999
dc.subject.fieldofresearchcode1109
dc.subject.fieldofresearchcode1702
dc.subject.fieldofresearchcode1701
dc.titleGlutamatergic and central cholinergic dysfunction in the CA1, CA2 and CA3 fields on spatial learning and memory in chronic cerebral ischemia—Induced vascular dementia of rats
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorFan, Yongjun


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