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dc.contributor.authorCai, Jinghua
dc.contributor.authorHe, Baoxia
dc.contributor.authorLi, Xinming
dc.contributor.authorSun, Minglei
dc.contributor.authorLam, Alfred King-Yin
dc.contributor.authorQiao, Bin
dc.contributor.authorQiu, Weiliu
dc.date.accessioned2017-08-14T04:52:39Z
dc.date.available2017-08-14T04:52:39Z
dc.date.issued2016
dc.identifier.issn1021-335X
dc.identifier.doi10.3892/or.2016.4851
dc.identifier.urihttp://hdl.handle.net/10072/142495
dc.description.abstractOct4 and Sox2 are pluripotent stem cell factors but the interplay between them in tumorigenesis is unclear. The aim of the present study was to investigate the roles of Oct4 and Sox2 in the reprogramming of oral cancer stem cells. One or both Oct4 and Sox2 were overexpressed in immortalized oral epithelial (hTERT+-OME) cells by lentivirus transduction. In addition, Oct4 and Sox2 proteins in two oral squamous cell carcinoma cell (OSCC) lines (Cal27 and primary cultured OSCC from a T2N2M0 patient) were individually or combinedly knocked down by shRNA. The results showed that the doubly transduced (Oct4+Sox2+) cells could trigger neoplasms in immunodeficient mice after lentivirus transduction, but single transduced (Oct4+ or Sox2+) cells had no tumor formation ability. The knockdown Sox2low and knockdown Oct4lowSox2low cells resulted in decreased tumor size in the immunodeficient mice but the single knockdown Oct4low cancer cells acquired more aggressive xenografts. Our findings suggest that Oct4+Sox2+ cells may be reprogrammed cancer stem cells inducing oral carcinogenesis.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpandidos Publications
dc.relation.ispartofpagefrom651
dc.relation.ispartofpageto658
dc.relation.ispartofjournalOncology Reports
dc.relation.ispartofvolume36
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchOncology and carcinogenesis not elsewhere classified
dc.subject.fieldofresearchcode3211
dc.subject.fieldofresearchcode321199
dc.titleRegulation of tumorigenesis in oral epithelial cells by defined reprogramming factors Oct4 and Sox2
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© Cai et al. 2016. This is an open access article distributed under the terms of a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International (CC BY-NC-ND 4.0) License, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
gro.hasfulltextFull Text
gro.griffith.authorLam, Alfred K.
gro.griffith.authorQiao, Bin


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