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  • Regulatory T cells may participate in Helicobacter pylori persistence in gastric MALT lymphoma: lessons from an animal model

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    KorolikPUB2812.pdf (5.465Mb)
    Author(s)
    Laur, Amandine Marine
    Floch, Pauline
    Chambonnier, Lucie
    Benejat, Lucie
    Korolik, Victoria
    Giese, Alban
    Dubus, Pierre
    Megraud, Francis
    Bandeira, Antonio
    Lehours, Philippe
    Griffith University Author(s)
    Korolik, Victoria
    Year published
    2016
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    Abstract
    It has been postulated that the emergence of autoimmune gastritis in neonatal thymectomised (d3Tx) BALB/c mice may be a consequence of post-surgery deficit in Tregs. In this study, previously obtained samples from d3Tx mice were used in order to determine whether thymectomy creates a deficit in this T cell subset thereby allowing the emergence of autoimmune phenomena as a prerequisite for GML. The splenic Treg reserve and the local recruitment of these cells in the gastric mucosa were investigated using complementary molecular and immunohistochemistry approaches. Higher Foxp3/CD3 ratios were found in the spleen of non-infected ...
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    It has been postulated that the emergence of autoimmune gastritis in neonatal thymectomised (d3Tx) BALB/c mice may be a consequence of post-surgery deficit in Tregs. In this study, previously obtained samples from d3Tx mice were used in order to determine whether thymectomy creates a deficit in this T cell subset thereby allowing the emergence of autoimmune phenomena as a prerequisite for GML. The splenic Treg reserve and the local recruitment of these cells in the gastric mucosa were investigated using complementary molecular and immunohistochemistry approaches. Higher Foxp3/CD3 ratios were found in the spleen of non-infected d3Tx mice compared to non-thymectomised (NTx) controls. These results indicate a relative enrichment of Tregs following thymectomy in adult mice. The absence of Treg depletion in d3Tx mice is in line with the absence of auto-immune gastritis in non-infected d3Tx mice. Higher levels of T cell and Treg infiltration were also found in the stomach of GML-developing d3Tx mice versus NTx mice. Surprisingly, inflammatory scores inversely correlated with the bacterial inoculum. The presence of a small Treg containing compartment among gastric biopsies of GML developing d3Tx mice may play a role in perseverance of a minimal bacterial numbers thereby maintaining an antigen-dependent stimulation and proliferation.
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    Journal Title
    Oncotarget
    Volume
    7
    Issue
    3
    Publisher URI
    http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=6492&path[]=20810
    DOI
    https://doi.org/10.18632/oncotarget.6492
    Copyright Statement
    © The Author(s) 2016. This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Subject
    Oncology and carcinogenesis
    Oncology and carcinogenesis not elsewhere classified
    MALT lymphoma
    Regulatory T cell
    Animal model
    Helicobacter pylori
    Publication URI
    http://hdl.handle.net/10072/142501
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    • Journal articles

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