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dc.contributor.authorChang, Anne B
dc.contributor.authorUpham, John W
dc.contributor.authorMasters, I Brent
dc.contributor.authorRedding, Gregory R
dc.contributor.authorGibson, Peter G
dc.contributor.authorMarchant, Julie M
dc.contributor.authorGrimwood, Keith
dc.date.accessioned2017-12-15T03:20:32Z
dc.date.available2017-12-15T03:20:32Z
dc.date.issued2016
dc.identifier.issn8755-6863
dc.identifier.doi10.1002/ppul.23351
dc.identifier.urihttp://hdl.handle.net/10072/142515
dc.description.abstractCough is the single most common reason for primary care physician visits and, when chronic, a frequent indication for specialist referrals. In children, a chronic cough (>4 weeks) is associated with increased morbidity and reduced quality of life. One common cause of childhood chronic cough is protracted bacterial bronchitis (PBB), especially in children aged <6 years. PBB is characterized by a chronic wet or productive cough without signs of an alternative cause and responds to 2 weeks of appropriate antibiotics, such as amoxicillin-clavulanate. Most children with PBB are unable to expectorate sputum. If bronchoscopy and bronchoalveolar lavage are performed, evidence of bronchitis and purulent endobronchial secretions are seen. Bronchoalveolar lavage specimens typically reveal marked neutrophil infiltration and culture large numbers of respiratory bacterial pathogens, especially Haemophilus influenzae. Although regarded as having a good prognosis, recurrences are common and if these are frequent or do not respond to antibiotic treatments of up to 4-weeks duration, the child should be investigated for other causes of chronic wet cough, such as bronchiectasis. The contribution of airway malacia and pathobiologic mechanisms of PBB remain uncertain and, other than reduced alveolar phagocytosis, evidence of systemic, or local immune deficiency is lacking. Instead, pulmonary defenses show activated innate immunity and increased gene expression of the interleukin-1β signalling pathway. Whether these changes in local inflammatory responses are cause or effect remains to be determined. It is likely that PBB and bronchiectasis are at the opposite ends of the same disease spectrum, so children with chronic wet cough require close monitoring.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherJohn Wiley & Sons, Inc.
dc.relation.ispartofpagefrom225
dc.relation.ispartofpageto242
dc.relation.ispartofissue3
dc.relation.ispartofjournalPediatric Pulmonology
dc.relation.ispartofvolume51
dc.subject.fieldofresearchPaediatrics and Reproductive Medicine not elsewhere classified
dc.subject.fieldofresearchPaediatrics and Reproductive Medicine
dc.subject.fieldofresearchcode111499
dc.subject.fieldofresearchcode1114
dc.titleProtracted bacterial bronchitis: The last decade and the road ahead
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorGrimwood, Keith


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