dc.contributor.author | Bazargan, Maryam | |
dc.contributor.author | Foster, David JR | |
dc.contributor.author | Muhlhausler, Beverly S | |
dc.contributor.author | Morrison, Janna L | |
dc.contributor.author | McMillen, ICaroline | |
dc.contributor.author | Davey, Andrew K | |
dc.date.accessioned | 2019-03-20T00:01:45Z | |
dc.date.available | 2019-03-20T00:01:45Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0890-6238 | |
dc.identifier.doi | 10.1016/j.reprotox.2016.04.008 | |
dc.identifier.uri | http://hdl.handle.net/10072/142583 | |
dc.description.abstract | Despite the fact that fetal drug exposure is common, the disposition of drugs in the fetus is poorly understood. This study aimed to investigate fetal placental and non-placental disposition of rosiglitazone in the pregnant ewe. Steady state was reached after day 5 of fetal infusion, and were ∼1.8 fold higher than maternal concentrations (P < 0.001). The AUC for fetal rosiglitazone concentration throughout the infusion was inversely correlated with placental and fetal weight. Metabolic activity of the fetal liver microsomes were ∼25 fold lower than maternal microsomes (P < 0.001). The findings suggest that trans‐placental transfer is the major route through which rosiglitazone is cleared from the fetal compartment, while non‐placental hepatic elimination makes only a minor contribution. This supports a limited capacity of the fetus for eliminating this class of drugs, and highlights the potential for drug toxicity when administering pharmacotherapy to the mother/fetus in human pregnancy. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartofpagefrom | 162 | |
dc.relation.ispartofpageto | 168 | |
dc.relation.ispartofjournal | Reproductive Toxicology | |
dc.relation.ispartofvolume | 61 | |
dc.subject.fieldofresearch | Pharmacology and pharmaceutical sciences | |
dc.subject.fieldofresearch | Pharmacology and pharmaceutical sciences not elsewhere classified | |
dc.subject.fieldofresearch | Health services and systems | |
dc.subject.fieldofresearch | Public health | |
dc.subject.fieldofresearch | Paediatrics | |
dc.subject.fieldofresearchcode | 3214 | |
dc.subject.fieldofresearchcode | 321499 | |
dc.subject.fieldofresearchcode | 4203 | |
dc.subject.fieldofresearchcode | 4206 | |
dc.subject.fieldofresearchcode | 3213 | |
dc.title | Limited fetal metabolism of rosiglitazone: Elimination via the maternal compartment in the pregnant ewe | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Davey, Andrew | |