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dc.contributor.authorBazargan, Maryam
dc.contributor.authorFoster, David JR
dc.contributor.authorMuhlhausler, Beverly S
dc.contributor.authorMorrison, Janna L
dc.contributor.authorMcMillen, ICaroline
dc.contributor.authorDavey, Andrew K
dc.date.accessioned2019-03-20T00:01:45Z
dc.date.available2019-03-20T00:01:45Z
dc.date.issued2016
dc.identifier.issn0890-6238
dc.identifier.doi10.1016/j.reprotox.2016.04.008
dc.identifier.urihttp://hdl.handle.net/10072/142583
dc.description.abstractDespite the fact that fetal drug exposure is common, the disposition of drugs in the fetus is poorly understood. This study aimed to investigate fetal placental and non-placental disposition of rosiglitazone in the pregnant ewe. Steady state was reached after day 5 of fetal infusion, and were ∼1.8 fold higher than maternal concentrations (P < 0.001). The AUC for fetal rosiglitazone concentration throughout the infusion was inversely correlated with placental and fetal weight. Metabolic activity of the fetal liver microsomes were ∼25 fold lower than maternal microsomes (P < 0.001). The findings suggest that trans‐placental transfer is the major route through which rosiglitazone is cleared from the fetal compartment, while non‐placental hepatic elimination makes only a minor contribution. This supports a limited capacity of the fetus for eliminating this class of drugs, and highlights the potential for drug toxicity when administering pharmacotherapy to the mother/fetus in human pregnancy.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom162
dc.relation.ispartofpageto168
dc.relation.ispartofjournalReproductive Toxicology
dc.relation.ispartofvolume61
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences not elsewhere classified
dc.subject.fieldofresearchHealth services and systems
dc.subject.fieldofresearchPublic health
dc.subject.fieldofresearchPaediatrics
dc.subject.fieldofresearchcode3214
dc.subject.fieldofresearchcode321499
dc.subject.fieldofresearchcode4203
dc.subject.fieldofresearchcode4206
dc.subject.fieldofresearchcode3213
dc.titleLimited fetal metabolism of rosiglitazone: Elimination via the maternal compartment in the pregnant ewe
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorDavey, Andrew


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